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- W3217711486 endingPage "7026" @default.
- W3217711486 startingPage "7026" @default.
- W3217711486 abstract "Early detection is a key factor in patient fate. Currently, multiple biomolecules have been recognized as biomarkers. Nevertheless, their identification is only the starting line on the way to their implementation in disease diagnosis. Although blood is the biofluid par excellence for the quantification of biomarkers, its extraction is uncomfortable and painful for many patients. In this sense, there is a gap in which saliva emerges as a non-invasive and valuable source of information, as it contains many of the biomarkers found in blood. Recent technological advances have made it possible to detect and quantify biomarkers in saliva samples. However, there are opportunity areas in terms of cost and complexity, which could be solved using simpler methodologies such as those based on enzymes. Many reviews have focused on presenting the state-of-the-art in identifying biomarkers in saliva samples. However, just a few of them provide critical analysis of technical elements for biomarker quantification in enzymatic methods for large-scale clinical applications. Thus, this review proposes enzymatic assays as a cost-effective alternative to overcome the limitations of current methods for the quantification of biomarkers in saliva, highlighting the technical and operational considerations necessary for sampling, method development, optimization, and validation." @default.
- W3217711486 created "2021-12-06" @default.
- W3217711486 creator A5009807307 @default.
- W3217711486 creator A5021054570 @default.
- W3217711486 creator A5043131686 @default.
- W3217711486 creator A5051402137 @default.
- W3217711486 date "2021-11-20" @default.
- W3217711486 modified "2023-10-16" @default.
- W3217711486 title "Enzymatic Methods for Salivary Biomarkers Detection: Overview and Current Challenges" @default.
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