FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217713552> ?p ?o ?g. }

• W3217713552 abstract "Metformin, the most commonly prescribed anti-diabetes medication, has multiple reported health benefits, including lowering the risks of cardiovascular disease and cancer, improving cognitive function with age, extending survival in diabetic patients, and, in several animal models, promoting youthful physiology and lifespan. Due to its longevity and health effects, metformin is now the focus of the first proposed clinical trial of an anti-aging drug-the Targeting Aging with Metformin (TAME) program. Genetic variation will likely influence outcomes when studying metformin health effects in human populations. To test for metformin impact in diverse genetic backgrounds, we measured lifespan and healthspan effects of metformin treatment in three Caenorhabditis species representing genetic variability greater than that between mice and humans. We show that metformin increases median survival in three C. elegans strains, but not in C. briggsae and C. tropicalis strains. In C. briggsae, metformin either has no impact on survival or decreases lifespan. In C. tropicalis, metformin decreases median survival in a dose-dependent manner. We show that metformin prolongs the period of youthful vigor in all C. elegans strains and in two C. briggsae strains, but that metformin has a negative impact on the locomotion of C. tropicalis strains. Our data demonstrate that metformin can be a robust promoter of healthy aging across different genetic backgrounds, but that genetic variation can determine whether metformin has positive, neutral, or negative lifespan/healthspan impact. These results underscore the importance of tailoring treatment to individuals when testing for metformin health benefits in diverse human populations." @default.
• W3217713552 created "2021-12-06" @default.
• W3217713552 creator A5001799176 @default.
• W3217713552 creator A5007965365 @default.
• W3217713552 creator A5008387980 @default.
• W3217713552 creator A5015744443 @default.
• W3217713552 creator A5016190367 @default.
• W3217713552 creator A5023145440 @default.
• W3217713552 creator A5027635740 @default.
• W3217713552 creator A5029198335 @default.
• W3217713552 creator A5033185211 @default.
• W3217713552 creator A5035012534 @default.
• W3217713552 creator A5036740389 @default.
• W3217713552 creator A5038126286 @default.
• W3217713552 creator A5042714807 @default.
• W3217713552 creator A5048933473 @default.
• W3217713552 creator A5053838220 @default.
• W3217713552 creator A5053985419 @default.
• W3217713552 creator A5054718460 @default.
• W3217713552 creator A5058189805 @default.
• W3217713552 creator A5068485154 @default.
• W3217713552 creator A5075322390 @default.
• W3217713552 creator A5077135762 @default.
• W3217713552 creator A5080344490 @default.
• W3217713552 creator A5089672893 @default.
• W3217713552 date "2021-11-27" @default.
• W3217713552 modified "2023-10-15" @default.
• W3217713552 title "Metformin treatment of diverse <i>Caenorhabditis</i> species reveals the importance of genetic background in longevity and healthspan extension outcomes" @default.
• W3217713552 cites W1573815132 @default.
• W3217713552 cites W1581882526 @default.
• W3217713552 cites W1963690635 @default.
• W3217713552 cites W1978993067 @default.
• W3217713552 cites W2053971316 @default.
• W3217713552 cites W2061008984 @default.
• W3217713552 cites W2067484587 @default.
• W3217713552 cites W2080654617 @default.
• W3217713552 cites W2082603625 @default.
• W3217713552 cites W2101468528 @default.
• W3217713552 cites W2102619694 @default.
• W3217713552 cites W2104106326 @default.
• W3217713552 cites W2104549677 @default.
• W3217713552 cites W2110427201 @default.
• W3217713552 cites W2119146677 @default.
• W3217713552 cites W2123921956 @default.
• W3217713552 cites W2131521454 @default.
• W3217713552 cites W2141060438 @default.
• W3217713552 cites W2149992227 @default.
• W3217713552 cites W2150131459 @default.
• W3217713552 cites W2152839556 @default.
• W3217713552 cites W2164361361 @default.
• W3217713552 cites W2179359265 @default.
• W3217713552 cites W2289120809 @default.
• W3217713552 cites W2408643388 @default.
• W3217713552 cites W2422981416 @default.
• W3217713552 cites W2564326418 @default.
• W3217713552 cites W2580425080 @default.
• W3217713552 cites W2590449460 @default.
• W3217713552 cites W2606022362 @default.
• W3217713552 cites W2742029199 @default.
• W3217713552 cites W2747311934 @default.
• W3217713552 cites W2762137272 @default.
• W3217713552 cites W2773309042 @default.
• W3217713552 cites W2886439407 @default.
• W3217713552 cites W2913428400 @default.
• W3217713552 cites W2929054648 @default.
• W3217713552 cites W2951476336 @default.
• W3217713552 cites W2952421334 @default.
• W3217713552 cites W2970182113 @default.
• W3217713552 cites W2972360351 @default.
• W3217713552 cites W2984558615 @default.
• W3217713552 cites W3029979236 @default.
• W3217713552 cites W3217713552 @default.
• W3217713552 doi "https://doi.org/10.1111/acel.13488" @default.
• W3217713552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34837316" @default.
• W3217713552 hasPublicationYear "2021" @default.
• W3217713552 type Work @default.
• W3217713552 sameAs 3217713552 @default.
• W3217713552 citedByCount "13" @default.
• W3217713552 countsByYear W32177135522021 @default.
• W3217713552 countsByYear W32177135522022 @default.
• W3217713552 countsByYear W32177135522023 @default.
• W3217713552 crossrefType "journal-article" @default.
• W3217713552 hasAuthorship W3217713552A5001799176 @default.
• W3217713552 hasAuthorship W3217713552A5007965365 @default.
• W3217713552 hasAuthorship W3217713552A5008387980 @default.
• W3217713552 hasAuthorship W3217713552A5015744443 @default.
• W3217713552 hasAuthorship W3217713552A5016190367 @default.
• W3217713552 hasAuthorship W3217713552A5023145440 @default.
• W3217713552 hasAuthorship W3217713552A5027635740 @default.
• W3217713552 hasAuthorship W3217713552A5029198335 @default.
• W3217713552 hasAuthorship W3217713552A5033185211 @default.
• W3217713552 hasAuthorship W3217713552A5035012534 @default.
• W3217713552 hasAuthorship W3217713552A5036740389 @default.
• W3217713552 hasAuthorship W3217713552A5038126286 @default.
• W3217713552 hasAuthorship W3217713552A5042714807 @default.
• W3217713552 hasAuthorship W3217713552A5048933473 @default.
• W3217713552 hasAuthorship W3217713552A5053838220 @default.
• W3217713552 hasAuthorship W3217713552A5053985419 @default.
• W3217713552 hasAuthorship W3217713552A5054718460 @default.
• W3217713552 hasAuthorship W3217713552A5058189805 @default.

• next