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• W3217726294 abstract "Helitrons are the only group of rolling-circle transposons that encode a transposase with a helicase domain (Hel), which belongs to the Pif1 family. Because Pif1 helicases are important components of eukaryotic genomes, it has been suggested that Hel domains probably originated after a host eukaryotic Pif1 gene was captured by a Helitron ancestor. However, the few analyses exploring the evolution of Helitron transposases (RepHel) have focused on its Rep domain, which is also present in other mobile genetic elements. Here, we used phylogenetic and nonmetric multidimensional scaling analyses to investigate the relationship between Hel domains and Pif1-like helicases from a variety of organisms. Our results reveal that Hel domains are only distantly related to genomic helicases from eukaryotes and prokaryotes, and thus are unlikely to have originated from a captured Pif1 gene. Based on this evidence, and on recent studies indicating that Rep domains are more closely related to rolling-circle plasmids and phages, we suggest that Helitrons are descendants of a RepHel-encoding prokaryotic plasmid element that invaded eukaryotic genomes before the radiation of its major groups. We discuss how a Pif1-like helicase domain might have favored the transposition of Helitrons in eukaryotes beyond simply unwinding DNA intermediates. Finally, we demonstrate that some examples in the literature describing genomic helicases from eukaryotes actually consist of Hel domains from Helitrons, a finding that underscores how transposons can hamper the analysis of eukaryotic genes. This investigation also revealed that two groups of land plants appear to have lost genomic Pif1 helicases independently." @default.
• W3217726294 created "2021-12-06" @default.
• W3217726294 creator A5014263836 @default.
• W3217726294 creator A5048010740 @default.
• W3217726294 date "2021-11-25" @default.
• W3217726294 modified "2023-09-26" @default.
• W3217726294 title "Pif1 Helicases and the Evidence for a Prokaryotic Origin of <i>Helitrons</i>" @default.
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• W3217726294 doi "https://doi.org/10.1093/molbev/msab334" @default.
• W3217726294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34850089" @default.
• W3217726294 hasPublicationYear "2021" @default.
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