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- W3217733679 abstract "Accumulating evidence has demonstrated that gut microbial-derived metabolite trimethylamine N-oxide (TMAO) plays a crucial role in the pathogenesis of many diseases and can be served as a prognostic biomarker for several cardiovascular disorders, including arrhythmia. Recently, some studies have documented that TMAO was associated with the occurrence, progression, recurrence, and embolism risk of atrial fibrillation (AF). The activation of related inflammatory signal pathways and the cardiac sympathetic nervous system (CSNS) caused by elevated TAMO may be the underlying mechanism. It is worth noting that intervention in the metabolic pathway of TMAO may be an underlying therapeutic target of AF. In addition, standardized and individualized treatment strategies in clinical practice may be of great significance for AF patients, particularly those with high serum TMAO concentrations. However, there are also contradictions in the current research on TMAO and AF. Moreover, notwithstanding the positive preclinical and clinical findings, data supporting a direct association between TMAO and AF is a paucity. Thus, conclusive evidence from preclinical studies and multi-center randomized controlled trials to reveal the essential relationship between TMAO and AF is needy. In this review, we have attempted to summarize recent studies on TMAO and AF, highlighted the potential therapeutic strategies for AF patients, followed by a discussion on directions for future research in this field." @default.
- W3217733679 created "2021-12-06" @default.
- W3217733679 creator A5000095164 @default.
- W3217733679 creator A5003231677 @default.
- W3217733679 creator A5029522351 @default.
- W3217733679 date "2021-11-01" @default.
- W3217733679 modified "2023-09-25" @default.
- W3217733679 title "The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies" @default.
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- W3217733679 doi "https://doi.org/10.2147/cia.s339590" @default.
- W3217733679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34876810" @default.
- W3217733679 hasPublicationYear "2021" @default.
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