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• W3217760492 abstract "Parkinson's disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD) due to the lack of representative models. To identify new strategies for developing representative models, we systematically summarized previous studies on PD-MCI and PDD and compared differences between existing models and diseases. Our initial search identified 5432 articles, of which 738 were duplicates. A total of 227 articles met our inclusion criteria and were included in the analysis. Models fell into three categories based on model design: neurotoxin-induced, transgenic, and combined. Although the neurotoxin-induced experimental model was the most common type that was used during every time period, transgenic and combined experimental models have gained significant recent attention. Unfortunately, there remains a big gap between ideal and actual experimental models. While each model has its own disadvantages, there have been tremendous advances in the development of PD models of cognitive impairment, and almost every model can verify a hypothesis about PD-MCI or PDD. Finally, our proposed strategies for developing novel models are as follows: a set of plans that integrate symptoms, biochemistry, neuroimaging, and other objective indicators to judge and identify that the novel model plays a key role in new strategies for developing representative models; novel models should simulate different clinical features of PD-MCI or PDD; inducible α-Syn overexpression and SH-SY5Y-A53T cellular models are good candidate models of PD-MCI or PDD." @default.
• W3217760492 created "2021-12-06" @default.
• W3217760492 creator A5008436646 @default.
• W3217760492 creator A5011267671 @default.
• W3217760492 creator A5051909174 @default.
• W3217760492 creator A5058632240 @default.
• W3217760492 creator A5066517120 @default.
• W3217760492 creator A5073930827 @default.
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• W3217760492 creator A5076887655 @default.
• W3217760492 creator A5077725004 @default.
• W3217760492 creator A5091124560 @default.
• W3217760492 date "2021-11-29" @default.
• W3217760492 modified "2023-09-26" @default.
• W3217760492 title "Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal" @default.
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