FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217761211> ?p ?o ?g. }

• W3217761211 endingPage "2102735" @default.
• W3217761211 startingPage "2102735" @default.
• W3217761211 abstract "Stem cells derived extracellular vesicles (EVs) conceive cues essential for tissue repair. Mammalian cartilaginous extracellular matrix (cECM) may not be optimally inductive for tracheal regeneration because of the granulomatous, instead of regenerative, responses in injured adult mammalian tracheas. Given the high regenerative capacity of gingiva, it is hypothesized human gingival mesenchymal stem cells derived EVs (gEVs) can induce mammalian tracheal epithelia regeneration. Coculturing chondrocytes with GMSCs produce abundant matrix bound gEVs (gMVs) in forming cartilaginous ECM, which are further preserved in acellular cECM (cACM) following mild, short-period decellularization. The results show that gMVs-cACM could be well anchored on polyglycerol sebacate microporous patch thus enforce the surgical suturability and mechanical strength. In rabbit tracheal defect, the gMVs-cACM patch induces rapid regeneration of vascularized ciliated columnar epithelium, which supports long-term survival of animals. gMVs-cACM treated groups exhibit proliferation of tracheal progenitors-basal epithelial cells, as well as, activation of JAK2/STAT1 pathway in reparative cells. This study departs from conventional focuses on tissue derived ECM and introduces a new approach for tracheal tissue regeneration." @default.
• W3217761211 created "2021-12-06" @default.
• W3217761211 creator A5002928018 @default.
• W3217761211 creator A5003759585 @default.
• W3217761211 creator A5009617595 @default.
• W3217761211 creator A5015718852 @default.
• W3217761211 creator A5015969575 @default.
• W3217761211 creator A5026850593 @default.
• W3217761211 date "2021-11-28" @default.
• W3217761211 modified "2023-10-16" @default.
• W3217761211 title "Cartilaginous Extracellular Matrix Enriched with Human Gingival Mesenchymal Stem Cells Derived “Matrix Bound Extracellular Vesicles” Enabled Functional Reconstruction of Tracheal Defect" @default.
• W3217761211 cites W1846832218 @default.
• W3217761211 cites W1949098412 @default.
• W3217761211 cites W1964478685 @default.
• W3217761211 cites W1968534897 @default.
• W3217761211 cites W1994054444 @default.
• W3217761211 cites W2010715204 @default.
• W3217761211 cites W2025572360 @default.
• W3217761211 cites W2050277110 @default.
• W3217761211 cites W2055375567 @default.
• W3217761211 cites W2059486645 @default.
• W3217761211 cites W2060261524 @default.
• W3217761211 cites W2102726602 @default.
• W3217761211 cites W2474756239 @default.
• W3217761211 cites W2498239438 @default.
• W3217761211 cites W2512969545 @default.
• W3217761211 cites W2522345229 @default.
• W3217761211 cites W2537923063 @default.
• W3217761211 cites W2587160918 @default.
• W3217761211 cites W2735252503 @default.
• W3217761211 cites W2735914888 @default.
• W3217761211 cites W2737628422 @default.
• W3217761211 cites W2748742702 @default.
• W3217761211 cites W2765632115 @default.
• W3217761211 cites W2792580051 @default.
• W3217761211 cites W2796990186 @default.
• W3217761211 cites W2799807555 @default.
• W3217761211 cites W2801123931 @default.
• W3217761211 cites W2803399583 @default.
• W3217761211 cites W2857568261 @default.
• W3217761211 cites W2883102068 @default.
• W3217761211 cites W2895011813 @default.
• W3217761211 cites W2896782101 @default.
• W3217761211 cites W2899003945 @default.
• W3217761211 cites W2909449354 @default.
• W3217761211 cites W2917473262 @default.
• W3217761211 cites W2925646157 @default.
• W3217761211 cites W2966510275 @default.
• W3217761211 cites W2970460847 @default.
• W3217761211 cites W2977346494 @default.
• W3217761211 cites W2984258583 @default.
• W3217761211 cites W2993996508 @default.
• W3217761211 cites W3000949947 @default.
• W3217761211 cites W3009137580 @default.
• W3217761211 cites W3033308446 @default.
• W3217761211 cites W3038440059 @default.
• W3217761211 cites W3093017132 @default.
• W3217761211 cites W3096545669 @default.
• W3217761211 cites W3102011730 @default.
• W3217761211 cites W3109961002 @default.
• W3217761211 cites W3114839312 @default.
• W3217761211 cites W3115705418 @default.
• W3217761211 cites W3117379398 @default.
• W3217761211 cites W3124334218 @default.
• W3217761211 cites W3124503483 @default.
• W3217761211 cites W3154203597 @default.
• W3217761211 cites W3190317733 @default.
• W3217761211 cites W3217761211 @default.
• W3217761211 cites W4243234982 @default.
• W3217761211 doi "https://doi.org/10.1002/advs.202102735" @default.
• W3217761211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34841733" @default.
• W3217761211 hasPublicationYear "2021" @default.
• W3217761211 type Work @default.
• W3217761211 sameAs 3217761211 @default.
• W3217761211 citedByCount "11" @default.
• W3217761211 countsByYear W32177612112021 @default.
• W3217761211 countsByYear W32177612112022 @default.
• W3217761211 countsByYear W32177612112023 @default.
• W3217761211 crossrefType "journal-article" @default.
• W3217761211 hasAuthorship W3217761211A5002928018 @default.
• W3217761211 hasAuthorship W3217761211A5003759585 @default.
• W3217761211 hasAuthorship W3217761211A5009617595 @default.
• W3217761211 hasAuthorship W3217761211A5015718852 @default.
• W3217761211 hasAuthorship W3217761211A5015969575 @default.
• W3217761211 hasAuthorship W3217761211A5026850593 @default.
• W3217761211 hasBestOaLocation W32177612113 @default.
• W3217761211 hasConcept C105702510 @default.
• W3217761211 hasConcept C106487976 @default.
• W3217761211 hasConcept C171056886 @default.
• W3217761211 hasConcept C185592680 @default.
• W3217761211 hasConcept C189165786 @default.
• W3217761211 hasConcept C190672674 @default.
• W3217761211 hasConcept C198826908 @default.
• W3217761211 hasConcept C201750760 @default.
• W3217761211 hasConcept C28328180 @default.
• W3217761211 hasConcept C43617362 @default.
• W3217761211 hasConcept C86803240 @default.
• W3217761211 hasConcept C95444343 @default.

• next