Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217764462> ?p ?o ?g. }
- W3217764462 endingPage "313" @default.
- W3217764462 startingPage "300" @default.
- W3217764462 abstract "Acute kidney injury (AKI) is characterized by a sudden loss of renal function and is associated with high morbidity and mortality. Tumor suppressor p53 and chemokine receptor CXCR4 were both implicated in the AKI pathology. Here, we report on the development and evaluation of polymeric CXCR4 antagonist (PCX) siRNA carrier for selective delivery to injured kidneys in AKI. Our results show that PCX/siRNA nanoparticles (polyplexes) provide protection against cisplatin injury to tubule cells in vitro when both CXCR4 and p53 are inhibited. The polyplexes selectively accumulate and are retained in the injured kidneys in cisplatin and bilateral ischemia reperfusion injury models of AKI. Treating AKI with the combined CXCR4 inhibition and p53 gene silencing with the PCX/sip53 polyplexes improves kidney function and decreases renal damage. Overall, our results suggest that the PCX/sip53 polyplexes have a significant potential to enhance renal accumulation in AKI and deliver therapeutic siRNA." @default.
- W3217764462 created "2021-12-06" @default.
- W3217764462 creator A5012677271 @default.
- W3217764462 creator A5016142488 @default.
- W3217764462 creator A5016187749 @default.
- W3217764462 creator A5017814395 @default.
- W3217764462 creator A5021866182 @default.
- W3217764462 creator A5032387963 @default.
- W3217764462 creator A5037707081 @default.
- W3217764462 creator A5037804457 @default.
- W3217764462 creator A5051001649 @default.
- W3217764462 creator A5054761857 @default.
- W3217764462 creator A5063800558 @default.
- W3217764462 creator A5085316750 @default.
- W3217764462 creator A5088551853 @default.
- W3217764462 date "2022-01-01" @default.
- W3217764462 modified "2023-10-16" @default.
- W3217764462 title "Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury" @default.
- W3217764462 cites W1511246213 @default.
- W3217764462 cites W1822254038 @default.
- W3217764462 cites W1963984954 @default.
- W3217764462 cites W1965553833 @default.
- W3217764462 cites W1967300023 @default.
- W3217764462 cites W1969622949 @default.
- W3217764462 cites W1978625692 @default.
- W3217764462 cites W1980227780 @default.
- W3217764462 cites W1984974003 @default.
- W3217764462 cites W1986240011 @default.
- W3217764462 cites W1991581690 @default.
- W3217764462 cites W2005659566 @default.
- W3217764462 cites W2007347651 @default.
- W3217764462 cites W2008337372 @default.
- W3217764462 cites W2011144569 @default.
- W3217764462 cites W2015585578 @default.
- W3217764462 cites W2026274122 @default.
- W3217764462 cites W2028618147 @default.
- W3217764462 cites W2030689322 @default.
- W3217764462 cites W2035188342 @default.
- W3217764462 cites W2045964638 @default.
- W3217764462 cites W2047830531 @default.
- W3217764462 cites W2057882250 @default.
- W3217764462 cites W2066995773 @default.
- W3217764462 cites W2067302150 @default.
- W3217764462 cites W2070270336 @default.
- W3217764462 cites W2070692494 @default.
- W3217764462 cites W2070996892 @default.
- W3217764462 cites W2073769825 @default.
- W3217764462 cites W2077967941 @default.
- W3217764462 cites W2089907021 @default.
- W3217764462 cites W2098361993 @default.
- W3217764462 cites W2101539899 @default.
- W3217764462 cites W2101800432 @default.
- W3217764462 cites W2102027021 @default.
- W3217764462 cites W2110048031 @default.
- W3217764462 cites W2111928834 @default.
- W3217764462 cites W2114241638 @default.
- W3217764462 cites W2114317477 @default.
- W3217764462 cites W2131419242 @default.
- W3217764462 cites W2134226393 @default.
- W3217764462 cites W2141559993 @default.
- W3217764462 cites W2146954847 @default.
- W3217764462 cites W2150903563 @default.
- W3217764462 cites W2155766138 @default.
- W3217764462 cites W2160807970 @default.
- W3217764462 cites W2161191894 @default.
- W3217764462 cites W2161740609 @default.
- W3217764462 cites W2169433972 @default.
- W3217764462 cites W2190204638 @default.
- W3217764462 cites W2220742453 @default.
- W3217764462 cites W2229789713 @default.
- W3217764462 cites W2233632661 @default.
- W3217764462 cites W2254311439 @default.
- W3217764462 cites W2303665768 @default.
- W3217764462 cites W2314507682 @default.
- W3217764462 cites W2333220158 @default.
- W3217764462 cites W2400603745 @default.
- W3217764462 cites W2405183840 @default.
- W3217764462 cites W2533733680 @default.
- W3217764462 cites W2562108284 @default.
- W3217764462 cites W2582602949 @default.
- W3217764462 cites W2599350803 @default.
- W3217764462 cites W2613483874 @default.
- W3217764462 cites W2617814074 @default.
- W3217764462 cites W2623546284 @default.
- W3217764462 cites W2745520112 @default.
- W3217764462 cites W2770786260 @default.
- W3217764462 cites W2802967146 @default.
- W3217764462 cites W2890622434 @default.
- W3217764462 cites W2892846120 @default.
- W3217764462 cites W2897245733 @default.
- W3217764462 cites W2961063174 @default.
- W3217764462 cites W2963597460 @default.
- W3217764462 cites W2998924959 @default.
- W3217764462 cites W3007722859 @default.
- W3217764462 cites W3100726004 @default.
- W3217764462 doi "https://doi.org/10.1016/j.jconrel.2021.11.029" @default.
- W3217764462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34826532" @default.
- W3217764462 hasPublicationYear "2022" @default.