Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217774890> ?p ?o ?g. }
- W3217774890 endingPage "114010" @default.
- W3217774890 startingPage "114010" @default.
- W3217774890 abstract "Due to unknown pathogenesis and unidentified drug target, no drug for the treatment of osteosarcoma (OS) has been launched to the market. Herein, thiazolidinone 1a was discovered as a hit compound by phenotypic screening with an in-house patrimonial collection of structural diversity. The following SAR (Structure-Activity Relationship) study affords the final water-soluble lead compound (R)-8i as a potential inhibitor for the proliferation of OS cells by the modulation of solubility of the compounds with remarkable cellular potency (IC50 = 21.9 nM for MNNG/HOS cells) and in vivo efficacy (52.9% inhibition OS growth in mice), as well as pharmacokinetic properties. (R)-8i also significantly suppresses OS cell migration in vitro and showed to be well-tolerated. Our preliminary investigation shows that the effects of (R)-8i are not dependent on p53 and myoferlin (MYOF). These results suggest that (R)-8i might be a potential drug candidate for OS treatment." @default.
- W3217774890 created "2021-12-06" @default.
- W3217774890 creator A5000753769 @default.
- W3217774890 creator A5007603239 @default.
- W3217774890 creator A5009647425 @default.
- W3217774890 creator A5016412264 @default.
- W3217774890 creator A5030439745 @default.
- W3217774890 creator A5048986033 @default.
- W3217774890 creator A5054584536 @default.
- W3217774890 creator A5070209285 @default.
- W3217774890 creator A5073761828 @default.
- W3217774890 creator A5074178064 @default.
- W3217774890 creator A5075171995 @default.
- W3217774890 creator A5081101328 @default.
- W3217774890 creator A5084123261 @default.
- W3217774890 creator A5084538882 @default.
- W3217774890 creator A5085399325 @default.
- W3217774890 date "2022-01-01" @default.
- W3217774890 modified "2023-10-03" @default.
- W3217774890 title "Novel 2-phenyl-3-(Pyridin-2-yl) thiazolidin-4-one derivatives as potent inhibitors for proliferation of osteosarcoma cells in vitro and in vivo" @default.
- W3217774890 cites W1971921242 @default.
- W3217774890 cites W1978677736 @default.
- W3217774890 cites W1999619322 @default.
- W3217774890 cites W2003238258 @default.
- W3217774890 cites W2005171216 @default.
- W3217774890 cites W2010068392 @default.
- W3217774890 cites W2022605490 @default.
- W3217774890 cites W2026104663 @default.
- W3217774890 cites W2055560696 @default.
- W3217774890 cites W2055931677 @default.
- W3217774890 cites W2058695279 @default.
- W3217774890 cites W2064880817 @default.
- W3217774890 cites W2068701052 @default.
- W3217774890 cites W2072146203 @default.
- W3217774890 cites W2073079990 @default.
- W3217774890 cites W2076892310 @default.
- W3217774890 cites W2077014658 @default.
- W3217774890 cites W2081341733 @default.
- W3217774890 cites W2083239828 @default.
- W3217774890 cites W2085334383 @default.
- W3217774890 cites W2091709211 @default.
- W3217774890 cites W2106033527 @default.
- W3217774890 cites W2109227311 @default.
- W3217774890 cites W2123059506 @default.
- W3217774890 cites W2128486176 @default.
- W3217774890 cites W2141566507 @default.
- W3217774890 cites W2145151966 @default.
- W3217774890 cites W2161364905 @default.
- W3217774890 cites W2161377790 @default.
- W3217774890 cites W2165849053 @default.
- W3217774890 cites W2264719596 @default.
- W3217774890 cites W2428552544 @default.
- W3217774890 cites W2508558839 @default.
- W3217774890 cites W2600397526 @default.
- W3217774890 cites W2608797079 @default.
- W3217774890 cites W2619130866 @default.
- W3217774890 cites W2742751028 @default.
- W3217774890 cites W2772058283 @default.
- W3217774890 cites W2884547170 @default.
- W3217774890 cites W2890627457 @default.
- W3217774890 cites W2911252837 @default.
- W3217774890 cites W2955338185 @default.
- W3217774890 cites W2966017082 @default.
- W3217774890 cites W2982646108 @default.
- W3217774890 cites W3008426906 @default.
- W3217774890 cites W3015213712 @default.
- W3217774890 cites W3018826743 @default.
- W3217774890 doi "https://doi.org/10.1016/j.ejmech.2021.114010" @default.
- W3217774890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34861640" @default.
- W3217774890 hasPublicationYear "2022" @default.
- W3217774890 type Work @default.
- W3217774890 sameAs 3217774890 @default.
- W3217774890 citedByCount "1" @default.
- W3217774890 crossrefType "journal-article" @default.
- W3217774890 hasAuthorship W3217774890A5000753769 @default.
- W3217774890 hasAuthorship W3217774890A5007603239 @default.
- W3217774890 hasAuthorship W3217774890A5009647425 @default.
- W3217774890 hasAuthorship W3217774890A5016412264 @default.
- W3217774890 hasAuthorship W3217774890A5030439745 @default.
- W3217774890 hasAuthorship W3217774890A5048986033 @default.
- W3217774890 hasAuthorship W3217774890A5054584536 @default.
- W3217774890 hasAuthorship W3217774890A5070209285 @default.
- W3217774890 hasAuthorship W3217774890A5073761828 @default.
- W3217774890 hasAuthorship W3217774890A5074178064 @default.
- W3217774890 hasAuthorship W3217774890A5075171995 @default.
- W3217774890 hasAuthorship W3217774890A5081101328 @default.
- W3217774890 hasAuthorship W3217774890A5084123261 @default.
- W3217774890 hasAuthorship W3217774890A5084538882 @default.
- W3217774890 hasAuthorship W3217774890A5085399325 @default.
- W3217774890 hasConcept C185592680 @default.
- W3217774890 hasConcept C193042331 @default.
- W3217774890 hasConcept C202751555 @default.
- W3217774890 hasConcept C207001950 @default.
- W3217774890 hasConcept C2777752497 @default.
- W3217774890 hasConcept C2777760704 @default.
- W3217774890 hasConcept C502942594 @default.
- W3217774890 hasConcept C54355233 @default.
- W3217774890 hasConcept C55493867 @default.