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- W3217793268 abstract "Rationale: Epidemiological and interventional studies showed that altered vitamin D status may be associated with decreased insulin synthesis, increased insulin resistance and increased risk of metabolic syndrome through several mechanisms.(1)Mechanisms were defined as stimulation of pancreatic beta cell function, decreased fat tissue, inflammatory markers. However, the exact mechanism lacks supporting evidence. Chromium seems to plays a vital role in regulation of carbohydrates and lipids, hence it enhance the signalling pathway and insulin action according to current studies, yet the exact reasoning is not fully understood.(2)There is no clinically defined state of chromium deficiency but T2DM has been shown to develop in low levels of chromium picolinate.Nevertheless, diets lacking essential trace elements is interrelated to reproducible structural or biochemical changes that are irreversible according to Espen guidelines." @default.
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- W3217793268 date "2021-12-01" @default.
- W3217793268 modified "2023-09-26" @default.
- W3217793268 title "Effects of vitamin d and chromium supplementation on prevention of diabetes type-a systematic review" @default.
- W3217793268 doi "https://doi.org/10.1016/j.clnesp.2021.09.445" @default.
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