Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217798935> ?p ?o ?g. }
- W3217798935 endingPage "592" @default.
- W3217798935 startingPage "585" @default.
- W3217798935 abstract "Melamine is an important chemical raw material used in industries, which has potential health risks to animals and humans. Current research mainly focuses on the toxic effects of high-dose melamine ingestion. However, there are few reports on whether melamine at the current limited standard dose has adverse effects on various tissues and organs, and whether there are sensitive target genes for risk evaluation. For this, 24 female Kunming mice were fed 0, 1.8-, 3.6-, and 7.2- mg/kg/d melamine via drinking water for consecutive 28 days, respectively. The morphological changes of the ovarian, hepatic, and renal tissues were firstly observed. The results demonstrated that the histopathology of ovary, liver, and especially in kidney had been altered by melamine intake in female. And then, the transcriptional levels of MAPK signaling genes including p38, ERK1, ERK2, JNK1, and JNK2 in kidneys were investigated by real-time PCR. The data showed that ERK1 and p38 mRNAs expressions were up-regulated significantly by melamine, suggesting that ERK1 and p38 transcriptional levels in the kidney might to be considered as candidate targets for lower-dose melamine toxicity. This study not only provides potential targets for the diagnosis and prevention of melamine damage, but also helps to assess the health risks of the current minimum allowable levels of melamine in food and environment." @default.
- W3217798935 created "2021-12-06" @default.
- W3217798935 creator A5002673921 @default.
- W3217798935 creator A5021636467 @default.
- W3217798935 creator A5022109570 @default.
- W3217798935 creator A5033592704 @default.
- W3217798935 creator A5052797419 @default.
- W3217798935 creator A5072832346 @default.
- W3217798935 creator A5076512552 @default.
- W3217798935 creator A5077000248 @default.
- W3217798935 date "2021-11-29" @default.
- W3217798935 modified "2023-10-03" @default.
- W3217798935 title "Melamine induced changes in histopathology of the main organs and transcriptional levels of <scp>MAPK</scp> signaling genes in kidneys of female mice" @default.
- W3217798935 cites W1251114829 @default.
- W3217798935 cites W1978735816 @default.
- W3217798935 cites W1998030276 @default.
- W3217798935 cites W2011781192 @default.
- W3217798935 cites W2020433244 @default.
- W3217798935 cites W2044172342 @default.
- W3217798935 cites W2052229909 @default.
- W3217798935 cites W2097804537 @default.
- W3217798935 cites W2108111306 @default.
- W3217798935 cites W2120530839 @default.
- W3217798935 cites W2145329920 @default.
- W3217798935 cites W2170696416 @default.
- W3217798935 cites W2259653456 @default.
- W3217798935 cites W2265025836 @default.
- W3217798935 cites W2345498148 @default.
- W3217798935 cites W2468510410 @default.
- W3217798935 cites W2505730996 @default.
- W3217798935 cites W2516188832 @default.
- W3217798935 cites W2531670861 @default.
- W3217798935 cites W2554974328 @default.
- W3217798935 cites W2586810893 @default.
- W3217798935 cites W2588841610 @default.
- W3217798935 cites W2604732530 @default.
- W3217798935 cites W2736548064 @default.
- W3217798935 cites W2755698536 @default.
- W3217798935 cites W2776036168 @default.
- W3217798935 cites W2783684854 @default.
- W3217798935 cites W2789314873 @default.
- W3217798935 cites W2898627936 @default.
- W3217798935 cites W2903596927 @default.
- W3217798935 cites W2914196009 @default.
- W3217798935 cites W2921293669 @default.
- W3217798935 cites W2945970528 @default.
- W3217798935 cites W2963017924 @default.
- W3217798935 cites W2981897000 @default.
- W3217798935 cites W2994289954 @default.
- W3217798935 cites W2997243558 @default.
- W3217798935 cites W3003319512 @default.
- W3217798935 cites W3005394308 @default.
- W3217798935 cites W3005674842 @default.
- W3217798935 cites W3007839861 @default.
- W3217798935 cites W3010101208 @default.
- W3217798935 cites W3010463873 @default.
- W3217798935 cites W3011737582 @default.
- W3217798935 cites W3016396267 @default.
- W3217798935 cites W3016821468 @default.
- W3217798935 cites W3017573903 @default.
- W3217798935 cites W3047867253 @default.
- W3217798935 cites W3133315466 @default.
- W3217798935 cites W3210309102 @default.
- W3217798935 cites W4211258630 @default.
- W3217798935 cites W3123873202 @default.
- W3217798935 doi "https://doi.org/10.1002/tox.23424" @default.
- W3217798935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34842327" @default.
- W3217798935 hasPublicationYear "2021" @default.
- W3217798935 type Work @default.
- W3217798935 sameAs 3217798935 @default.
- W3217798935 citedByCount "4" @default.
- W3217798935 countsByYear W32177989352022 @default.
- W3217798935 countsByYear W32177989352023 @default.
- W3217798935 crossrefType "journal-article" @default.
- W3217798935 hasAuthorship W3217798935A5002673921 @default.
- W3217798935 hasAuthorship W3217798935A5021636467 @default.
- W3217798935 hasAuthorship W3217798935A5022109570 @default.
- W3217798935 hasAuthorship W3217798935A5033592704 @default.
- W3217798935 hasAuthorship W3217798935A5052797419 @default.
- W3217798935 hasAuthorship W3217798935A5072832346 @default.
- W3217798935 hasAuthorship W3217798935A5076512552 @default.
- W3217798935 hasAuthorship W3217798935A5077000248 @default.
- W3217798935 hasConcept C126322002 @default.
- W3217798935 hasConcept C134018914 @default.
- W3217798935 hasConcept C142724271 @default.
- W3217798935 hasConcept C178790620 @default.
- W3217798935 hasConcept C185592680 @default.
- W3217798935 hasConcept C2775979504 @default.
- W3217798935 hasConcept C2780091579 @default.
- W3217798935 hasConcept C2780862370 @default.
- W3217798935 hasConcept C29730261 @default.
- W3217798935 hasConcept C33070731 @default.
- W3217798935 hasConcept C46699223 @default.
- W3217798935 hasConcept C544855455 @default.
- W3217798935 hasConcept C55493867 @default.
- W3217798935 hasConcept C57074206 @default.
- W3217798935 hasConcept C62478195 @default.
- W3217798935 hasConcept C71315377 @default.