FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217798947> ?p ?o ?g. }

• W3217798947 abstract "As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility. Although accumulating evidence indicates that PM exposure is associated with increased male infertility rates, the mechanism by which PM is involved is not well understood. Here, we found that short-term PM exposure activated NF-κB signaling in mouse Leydig cells and testes and leading to asymptomatic orchitis. Analyzing the mitochondrial abundance and cGAMP levels in PM exposed mouse Leydig cells, we found that PM exposure induced mitochondrial injury and mtDNA release, leading to inflammation via the cGAS-STING axis. We also found that aspirin-induced acetylation of cGAS inhibited the inflammation in mice after PM exposure, especially in the testes. Moreover, aspirin pretreatment rescued offspring growth in PM-exposed mice. In summary, our study not only provides evidence that PM-induced asymptomatic orchitis in mice may be amenable to aspirin pre-treatment by acetylating cGAS, but also provides a potential explanation for male infertility caused by air pollutants." @default.
• W3217798947 created "2021-12-06" @default.
• W3217798947 creator A5010238428 @default.
• W3217798947 creator A5012514369 @default.
• W3217798947 creator A5013648181 @default.
• W3217798947 creator A5017390213 @default.
• W3217798947 creator A5023363049 @default.
• W3217798947 creator A5054764279 @default.
• W3217798947 creator A5063404503 @default.
• W3217798947 creator A5063629043 @default.
• W3217798947 creator A5084130934 @default.
• W3217798947 date "2021-12-01" @default.
• W3217798947 modified "2023-10-05" @default.
• W3217798947 title "Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling" @default.
• W3217798947 cites W2015423358 @default.
• W3217798947 cites W2016131266 @default.
• W3217798947 cites W2027889155 @default.
• W3217798947 cites W2031182394 @default.
• W3217798947 cites W2035232303 @default.
• W3217798947 cites W2041540563 @default.
• W3217798947 cites W2060004514 @default.
• W3217798947 cites W2060610804 @default.
• W3217798947 cites W2069797191 @default.
• W3217798947 cites W2076810056 @default.
• W3217798947 cites W2080256413 @default.
• W3217798947 cites W2104278759 @default.
• W3217798947 cites W2159811344 @default.
• W3217798947 cites W2165748936 @default.
• W3217798947 cites W2170932503 @default.
• W3217798947 cites W2262624703 @default.
• W3217798947 cites W2473346509 @default.
• W3217798947 cites W2534879302 @default.
• W3217798947 cites W2574819148 @default.
• W3217798947 cites W2583676372 @default.
• W3217798947 cites W2592323922 @default.
• W3217798947 cites W2593970154 @default.
• W3217798947 cites W2602155109 @default.
• W3217798947 cites W2626574391 @default.
• W3217798947 cites W2735682341 @default.
• W3217798947 cites W2741412919 @default.
• W3217798947 cites W2762472682 @default.
• W3217798947 cites W2768671952 @default.
• W3217798947 cites W2782578484 @default.
• W3217798947 cites W2793014591 @default.
• W3217798947 cites W2793372731 @default.
• W3217798947 cites W2797138717 @default.
• W3217798947 cites W2809929364 @default.
• W3217798947 cites W2889077654 @default.
• W3217798947 cites W2902238392 @default.
• W3217798947 cites W2916717448 @default.
• W3217798947 cites W2921875691 @default.
• W3217798947 cites W3003487669 @default.
• W3217798947 cites W3033299895 @default.
• W3217798947 cites W3104209159 @default.
• W3217798947 cites W3136592470 @default.
• W3217798947 cites W3160690824 @default.
• W3217798947 cites W4248457832 @default.
• W3217798947 cites W813084057 @default.
• W3217798947 doi "https://doi.org/10.3389/fimmu.2021.734546" @default.
• W3217798947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34925318" @default.
• W3217798947 hasPublicationYear "2021" @default.
• W3217798947 type Work @default.
• W3217798947 sameAs 3217798947 @default.
• W3217798947 citedByCount "3" @default.
• W3217798947 countsByYear W32177989472022 @default.
• W3217798947 countsByYear W32177989472023 @default.
• W3217798947 crossrefType "journal-article" @default.
• W3217798947 hasAuthorship W3217798947A5010238428 @default.
• W3217798947 hasAuthorship W3217798947A5012514369 @default.
• W3217798947 hasAuthorship W3217798947A5013648181 @default.
• W3217798947 hasAuthorship W3217798947A5017390213 @default.
• W3217798947 hasAuthorship W3217798947A5023363049 @default.
• W3217798947 hasAuthorship W3217798947A5054764279 @default.
• W3217798947 hasAuthorship W3217798947A5063404503 @default.
• W3217798947 hasAuthorship W3217798947A5063629043 @default.
• W3217798947 hasAuthorship W3217798947A5084130934 @default.
• W3217798947 hasBestOaLocation W32177989471 @default.
• W3217798947 hasConcept C112672928 @default.
• W3217798947 hasConcept C126322002 @default.
• W3217798947 hasConcept C134018914 @default.
• W3217798947 hasConcept C142724271 @default.
• W3217798947 hasConcept C16685009 @default.
• W3217798947 hasConcept C203014093 @default.
• W3217798947 hasConcept C2776914184 @default.
• W3217798947 hasConcept C2777338322 @default.
• W3217798947 hasConcept C2777469505 @default.
• W3217798947 hasConcept C2777628954 @default.
• W3217798947 hasConcept C2777688143 @default.
• W3217798947 hasConcept C2777910003 @default.
• W3217798947 hasConcept C2779234561 @default.
• W3217798947 hasConcept C54355233 @default.
• W3217798947 hasConcept C71924100 @default.
• W3217798947 hasConcept C86803240 @default.
• W3217798947 hasConceptScore W3217798947C112672928 @default.
• W3217798947 hasConceptScore W3217798947C126322002 @default.
• W3217798947 hasConceptScore W3217798947C134018914 @default.
• W3217798947 hasConceptScore W3217798947C142724271 @default.
• W3217798947 hasConceptScore W3217798947C16685009 @default.
• W3217798947 hasConceptScore W3217798947C203014093 @default.
• W3217798947 hasConceptScore W3217798947C2776914184 @default.

• next