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- W3217809111 endingPage "2582" @default.
- W3217809111 startingPage "2565" @default.
- W3217809111 abstract "As the main exchanger of electroneutral NaCl absorption, sodium-hydrogen exchanger isoform 3 (NHE3) circulates in the epithelial brush border (BB) and intracellular compartments in a multi-protein complex. The size of the NHE3 complex changes during rapid regulation events. Recycling regulation of NHE3 in epithelial cells can be roughly divided into three stages. First, when stimulated by Ca2+, cGMP, and cAMP-dependent signaling pathways, NHE3 is converted from an immobile complex found at the apical microvilli (MV) into an easily internalized and mobile form that relocates to a compartment near the base of the MV. Second, NHE3 is internalized by clathrin and albumin-dependent pathways into cytoplasmic endosomal compartments, where the complex is reprocessed and reassembled. Finally, NHE3 is translocated from the recycling endosomes (REs) to the apex of epithelial cells, a process that can be stimulated by an increase in sodium-glucose cotransporter 1 (SGLT1) activity, epidermal growth factor receptor (EGFR) signaling, Ca2+ signaling, and binding to βPix and SH3 and multiple ankyrin repeat domains 2 (Shank2) proteins. This review describes the molecular steps and protein interactions involved in the recycling movement of NHE3 from the apex of epithelial cells, into vesicles, where it is reprocessed and reassembled, and returned to its original location on the plasma membrane, where it exerts its physiological function." @default.
- W3217809111 created "2021-12-06" @default.
- W3217809111 creator A5021846077 @default.
- W3217809111 creator A5024037932 @default.
- W3217809111 creator A5028957931 @default.
- W3217809111 creator A5052792262 @default.
- W3217809111 creator A5054161527 @default.
- W3217809111 creator A5087062339 @default.
- W3217809111 date "2021-11-25" @default.
- W3217809111 modified "2023-10-18" @default.
- W3217809111 title "The recycling regulation of sodium-hydrogen exchanger isoform 3(NHE3) in epithelial cells" @default.
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