Matches in SemOpenAlex for { <https://semopenalex.org/work/W321802398> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W321802398 abstract "Deep femoral arteries (DFA) of rats show hypoxic (3% PO2) vasoconstriction (HVC), which required a pretone by α-adrenergic (PhE) stimulation. Nifedipine completely abolished HVC. HVC appeared to be endothelium-independent. However, both NO synthase (NOS) inhibitor (L-NAME) and soluble guanylate cyclase (sGC) inhibitor (ODQ) largely augmented the PhE-induced contraction of DFA, upon which no further HVC was elicited. Upon the PhE-induced pretone, strong contraction was induced by NOX4 inhibitor (DPI or plumbagin), and additional hypoxia induced relaxation instead of HVC. Pretreatment with NOX2 inhibitor (apocynin) or with ROS scavengers did not inhibit HVC. The inhibitors of mitochondrial electron transport chain (rotenone, antimycin A, NaCN) or uncoupler (CCCP) suppressed HVC as well as the PhE-induced pretone, indicating a general inhibition of contractility. Also, RhoA-dependent kinase inhibitors (Y27632 and fasudil) suppressed HVC along with the inhibition of pretone. Taken together, it is suggested that NOX4 might play a critical early step for the HVC; NOX4-dependent hypoxic inhibition of NOS/sGC might have augmented the PhE-induced contraction of DFA. The HVC of skeletal arteries might have a physiological implication for matching the imbalance between the cardiac output and the skeletal blood flow under severe exercise or emergent hypoxia combined with increased sympathetic tone. This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF 2011-0017379 and 2011-0001175)." @default.
- W321802398 created "2016-06-24" @default.
- W321802398 creator A5006288701 @default.
- W321802398 creator A5027633905 @default.
- W321802398 creator A5034315022 @default.
- W321802398 creator A5035019435 @default.
- W321802398 creator A5047317842 @default.
- W321802398 date "2012-04-01" @default.
- W321802398 modified "2023-10-15" @default.
- W321802398 title "Hypoxic vasoconstriction of rat skeletal artery mediated by NOX4 and NOS/sGC pathway" @default.
- W321802398 doi "https://doi.org/10.1096/fasebj.26.1_supplement.896.4" @default.
- W321802398 hasPublicationYear "2012" @default.
- W321802398 type Work @default.
- W321802398 sameAs 321802398 @default.
- W321802398 citedByCount "0" @default.
- W321802398 crossrefType "journal-article" @default.
- W321802398 hasAuthorship W321802398A5006288701 @default.
- W321802398 hasAuthorship W321802398A5027633905 @default.
- W321802398 hasAuthorship W321802398A5034315022 @default.
- W321802398 hasAuthorship W321802398A5035019435 @default.
- W321802398 hasAuthorship W321802398A5047317842 @default.
- W321802398 hasConcept C126322002 @default.
- W321802398 hasConcept C134018914 @default.
- W321802398 hasConcept C163415756 @default.
- W321802398 hasConcept C170493617 @default.
- W321802398 hasConcept C184235292 @default.
- W321802398 hasConcept C185592680 @default.
- W321802398 hasConcept C201800478 @default.
- W321802398 hasConcept C2776048814 @default.
- W321802398 hasConcept C2777209548 @default.
- W321802398 hasConcept C2779719074 @default.
- W321802398 hasConcept C2779765511 @default.
- W321802398 hasConcept C2779961880 @default.
- W321802398 hasConcept C2908929049 @default.
- W321802398 hasConcept C48349386 @default.
- W321802398 hasConcept C55493867 @default.
- W321802398 hasConcept C57900726 @default.
- W321802398 hasConcept C68923441 @default.
- W321802398 hasConcept C71924100 @default.
- W321802398 hasConcept C84393581 @default.
- W321802398 hasConcept C86803240 @default.
- W321802398 hasConcept C98274493 @default.
- W321802398 hasConceptScore W321802398C126322002 @default.
- W321802398 hasConceptScore W321802398C134018914 @default.
- W321802398 hasConceptScore W321802398C163415756 @default.
- W321802398 hasConceptScore W321802398C170493617 @default.
- W321802398 hasConceptScore W321802398C184235292 @default.
- W321802398 hasConceptScore W321802398C185592680 @default.
- W321802398 hasConceptScore W321802398C201800478 @default.
- W321802398 hasConceptScore W321802398C2776048814 @default.
- W321802398 hasConceptScore W321802398C2777209548 @default.
- W321802398 hasConceptScore W321802398C2779719074 @default.
- W321802398 hasConceptScore W321802398C2779765511 @default.
- W321802398 hasConceptScore W321802398C2779961880 @default.
- W321802398 hasConceptScore W321802398C2908929049 @default.
- W321802398 hasConceptScore W321802398C48349386 @default.
- W321802398 hasConceptScore W321802398C55493867 @default.
- W321802398 hasConceptScore W321802398C57900726 @default.
- W321802398 hasConceptScore W321802398C68923441 @default.
- W321802398 hasConceptScore W321802398C71924100 @default.
- W321802398 hasConceptScore W321802398C84393581 @default.
- W321802398 hasConceptScore W321802398C86803240 @default.
- W321802398 hasConceptScore W321802398C98274493 @default.
- W321802398 hasFunder F4320322120 @default.
- W321802398 hasFunder F4320322349 @default.
- W321802398 hasIssue "S1" @default.
- W321802398 hasLocation W3218023981 @default.
- W321802398 hasOpenAccess W321802398 @default.
- W321802398 hasPrimaryLocation W3218023981 @default.
- W321802398 hasRelatedWork W1493380826 @default.
- W321802398 hasRelatedWork W1997147144 @default.
- W321802398 hasRelatedWork W2077582105 @default.
- W321802398 hasRelatedWork W2126725296 @default.
- W321802398 hasRelatedWork W2234295481 @default.
- W321802398 hasRelatedWork W3136531359 @default.
- W321802398 hasRelatedWork W3176048087 @default.
- W321802398 hasRelatedWork W321802398 @default.
- W321802398 hasRelatedWork W34898393 @default.
- W321802398 hasRelatedWork W83373035 @default.
- W321802398 hasVolume "26" @default.
- W321802398 isParatext "false" @default.
- W321802398 isRetracted "false" @default.
- W321802398 magId "321802398" @default.
- W321802398 workType "article" @default.