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- W321823080 abstract "What I would like to do for the end of this session is add a little caveat to myoblast transplantation. Basically, the caveat comes from work we have been doing on understanding the role of dystrophin in normal muscle function. When Eric Hoffman first came to me concerning collaboration with Terry Partridge on cell transplantation, I was a bit skeptical about the feasibility of the procedure. But as the experiments progressed, they looked more and more promising. The nagging question in both my mind and others was the occurrence of manifesting carriers. Having two cell populations (those capable of producing dystrophin and those incapable) one would expect that a carrier, much like a recipient of a transplant, would be expected to compensate for the abnormal cells and with time have only dystrophin producing cells. One way to address the issue would be to follow the fate of the two cell populations during embryonic development in an obligate carrier. These experiments would only be possible in an animal model, so we set up a collaboration with Simon Watkins to study cross-sections of muscle taken from obligate mdx carrier mice at different times during normal development. As might be predicted, early in development there were obvious dystrophin negative fibers among dystrophin positive ones. The number of negative fibers decreased with time such that by 60 days after birth, the vast majority of fibers were dystrophin positive." @default.
- W321823080 created "2016-06-24" @default.
- W321823080 creator A5048436189 @default.
- W321823080 date "1990-01-01" @default.
- W321823080 modified "2023-09-25" @default.
- W321823080 title "The Dilemma of Manifesting Carriers in the Context of Myoblast Transplantation" @default.
- W321823080 doi "https://doi.org/10.1007/978-1-4684-5865-7_33" @default.
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