FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W323229595> ?p ?o ?g. }

• W323229595 endingPage "87" @default.
• W323229595 startingPage "79" @default.
• W323229595 abstract "This multicenter, randomized, single-blind study compared the efficacy and safety of a new, twice-daily formulation of amoxycillin/clavulanate (Augmenting) with the standard three-times-daily formulation. Children with a clinical diagnosis of acute otitis media, aged between 2 months and 12 years, received either amoxycillin/clavulanate 45/6.4 mg/kg/day twice-daily (b.d.) (range 38.3/5.5-76.2/10.9 mg/kg/day) or amoxycillin/clavulanate 40/10 mg/kg/day three-times-daily (t.d.s.) (range 25/6.25-56/14 mg/kg/day) for 7 or 10 days. Patients were evaluated during therapy (Days 3-5), at the end of therapy (Days 7-12) and at follow-up (Days 38-42). At the end of therapy, for the intent-to-treat and per-protocol populations, respectively, clinical success (cure) was achieved by approximately 94% of patients in both treatment groups. A successful bacteriological response at the end of therapy (Visit 3) was documented in 7/9 patients (77.8%) in the twice-daily group and in 11/13 patients (84.6%) in the three-times-daily group. At follow-up (Visit 4), 93.3% of patients in the twice-daily group and 87.9% in the three-times-daily group continued to have a clinically successful response. Both treatment regimens were well tolerated, with most adverse events being of a mild-moderate and transient nature. The most common treatment-related adverse event was diarrhea, occurring in 7.2% of patients in the twice-daily group and in 10.7% of the three-times-daily group. In total, 173 patients (82.8%) in the twice-daily group and 151 patients (73.3%) in the three-times-daily group were compliant with medication. In conclusion, this study confirms that b.d. amoxycillin/clavulanate is an effective treatment for pediatric acute otitis media and demonstrates that the b.d. and t.d.s. formulations of amoxycillin/clavulanate produce equivalent efficacy. Furthermore, there was a trend towards a higher level of compliance and a lower incidence of drug-related adverse events in the twice-daily compared with the three-times-daily treatment group." @default.
• W323229595 created "2016-06-24" @default.
• W323229595 creator A5003832042 @default.
• W323229595 creator A5027733926 @default.
• W323229595 creator A5036436273 @default.
• W323229595 date "2000-02-01" @default.
• W323229595 modified "2023-09-27" @default.
• W323229595 title "Efficacy and safety of amoxycillin/clavulanate (Augmentin) twice daily versus three times daily in the treatment of acute otitis media in children. The Augmentin 454 Study Group." @default.
• W323229595 cites W1970252292 @default.
• W323229595 cites W1970461606 @default.
• W323229595 cites W1970745908 @default.
• W323229595 cites W1973109313 @default.
• W323229595 cites W2017951949 @default.
• W323229595 cites W2020151282 @default.
• W323229595 cites W2027166036 @default.
• W323229595 cites W2086160705 @default.
• W323229595 cites W2093657336 @default.
• W323229595 cites W2107630864 @default.
• W323229595 cites W2117587576 @default.
• W323229595 cites W2152487351 @default.
• W323229595 cites W2159189010 @default.
• W323229595 cites W2231520801 @default.
• W323229595 cites W2407019665 @default.
• W323229595 cites W2474042981 @default.
• W323229595 doi "https://doi.org/10.1179/joc.2000.12.1.79" @default.
• W323229595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10768519" @default.
• W323229595 hasPublicationYear "2000" @default.
• W323229595 type Work @default.
• W323229595 sameAs 323229595 @default.
• W323229595 citedByCount "10" @default.
• W323229595 countsByYear W3232295952015 @default.
• W323229595 countsByYear W3232295952017 @default.
• W323229595 countsByYear W3232295952021 @default.
• W323229595 countsByYear W3232295952023 @default.
• W323229595 crossrefType "journal-article" @default.
• W323229595 hasAuthorship W323229595A5003832042 @default.
• W323229595 hasAuthorship W323229595A5027733926 @default.
• W323229595 hasAuthorship W323229595A5036436273 @default.
• W323229595 hasConcept C126322002 @default.
• W323229595 hasConcept C141071460 @default.
• W323229595 hasConcept C168563851 @default.
• W323229595 hasConcept C197934379 @default.
• W323229595 hasConcept C2779454058 @default.
• W323229595 hasConcept C2779708577 @default.
• W323229595 hasConcept C2779802037 @default.
• W323229595 hasConcept C42219234 @default.
• W323229595 hasConcept C501593827 @default.
• W323229595 hasConcept C71924100 @default.
• W323229595 hasConcept C86803240 @default.
• W323229595 hasConcept C89423630 @default.
• W323229595 hasConceptScore W323229595C126322002 @default.
• W323229595 hasConceptScore W323229595C141071460 @default.
• W323229595 hasConceptScore W323229595C168563851 @default.
• W323229595 hasConceptScore W323229595C197934379 @default.
• W323229595 hasConceptScore W323229595C2779454058 @default.
• W323229595 hasConceptScore W323229595C2779708577 @default.
• W323229595 hasConceptScore W323229595C2779802037 @default.
• W323229595 hasConceptScore W323229595C42219234 @default.
• W323229595 hasConceptScore W323229595C501593827 @default.
• W323229595 hasConceptScore W323229595C71924100 @default.
• W323229595 hasConceptScore W323229595C86803240 @default.
• W323229595 hasConceptScore W323229595C89423630 @default.
• W323229595 hasIssue "1" @default.
• W323229595 hasLocation W3232295951 @default.
• W323229595 hasOpenAccess W323229595 @default.
• W323229595 hasPrimaryLocation W3232295951 @default.
• W323229595 hasRelatedWork W1971160910 @default.
• W323229595 hasRelatedWork W2000308367 @default.
• W323229595 hasRelatedWork W2044979983 @default.
• W323229595 hasRelatedWork W2057107366 @default.
• W323229595 hasRelatedWork W2093657336 @default.
• W323229595 hasRelatedWork W2609462884 @default.
• W323229595 hasRelatedWork W3009124764 @default.
• W323229595 hasRelatedWork W3016074783 @default.
• W323229595 hasRelatedWork W3047193350 @default.
• W323229595 hasRelatedWork W3177494877 @default.
• W323229595 hasVolume "12" @default.
• W323229595 isParatext "false" @default.
• W323229595 isRetracted "false" @default.
• W323229595 magId "323229595" @default.
• W323229595 workType "article" @default.