Matches in SemOpenAlex for { <https://semopenalex.org/work/W323252210> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W323252210 abstract "Abstract : ERG, a member of the ETS transcription factor family, is frequently overexpressed in prostate cancer as a result of its fusion to the androgenresponsive Tmprss2 gene. Different genomic rearrangements and alternative splicing events around the junction region lead to multiple combination of Tmprss2:ERG fusion transcripts that correlate with different tumor aggressiveness, but their specific functions and biological activities are still unclear. The complexity of ERG expression pattern is compounded by the use of alternative promoters, splice sites, polyadenylation sites and translation initiation sites in both the native and fusion contexts. Our systematic characterization of native ERG and Tmprss2:ERG variants reveals that their different oncogenic potential is impacted by the status of the Ets domain and the configuration of the 5 UTR region. In particular, expression and activity of functional ERG and Tmprss2:ERG variants are influenced both by translation initiation signals within the different isoforms and by inhibitory upstream Open Reading Frames (uORF) in their 5 UTRs. Stable expression of ERG and Tmprss2:ERG variants promoted cell migration/invasion, induced a block of proliferation and induced a senescence-like state, suggesting a role for these variants in the prostate tumorigenesis process. In addition to Tmprss2:ERG fusion products, a group of related native ERG isoforms is also highly over-expressed in fusioncarrying prostate cancers, and share the same translation initiation site (in ERG exon 4) with the commonly observed Tmprss2 exon1 joined to ERG exon 4 (T1:E4) fusion-derived variant. Usage of this ATG can be preferentially down-regulated by directed antisense-based compounds, possibly representing the basis of a targeted approach that distinguishes between tumor associated and normal ERG." @default.
- W323252210 created "2016-06-24" @default.
- W323252210 creator A5039617409 @default.
- W323252210 creator A5045566813 @default.
- W323252210 creator A5048122663 @default.
- W323252210 creator A5083532161 @default.
- W323252210 date "2010-09-01" @default.
- W323252210 modified "2023-09-24" @default.
- W323252210 title "Oncogenicity and Selective Inhibition of ERG Splicing Variants in Prostate Cancer" @default.
- W323252210 doi "https://doi.org/10.21236/ada544999" @default.
- W323252210 hasPublicationYear "2010" @default.
- W323252210 type Work @default.
- W323252210 sameAs 323252210 @default.
- W323252210 citedByCount "0" @default.
- W323252210 crossrefType "report" @default.
- W323252210 hasAuthorship W323252210A5039617409 @default.
- W323252210 hasAuthorship W323252210A5045566813 @default.
- W323252210 hasAuthorship W323252210A5048122663 @default.
- W323252210 hasAuthorship W323252210A5083532161 @default.
- W323252210 hasConcept C103796816 @default.
- W323252210 hasConcept C104317684 @default.
- W323252210 hasConcept C111829193 @default.
- W323252210 hasConcept C121608353 @default.
- W323252210 hasConcept C126322002 @default.
- W323252210 hasConcept C150194340 @default.
- W323252210 hasConcept C169760540 @default.
- W323252210 hasConcept C194583182 @default.
- W323252210 hasConcept C205003668 @default.
- W323252210 hasConcept C2777093970 @default.
- W323252210 hasConcept C2778042024 @default.
- W323252210 hasConcept C2779134260 @default.
- W323252210 hasConcept C2780192828 @default.
- W323252210 hasConcept C3008058167 @default.
- W323252210 hasConcept C36823959 @default.
- W323252210 hasConcept C502942594 @default.
- W323252210 hasConcept C524204448 @default.
- W323252210 hasConcept C54355233 @default.
- W323252210 hasConcept C555283112 @default.
- W323252210 hasConcept C71924100 @default.
- W323252210 hasConcept C81350143 @default.
- W323252210 hasConcept C86803240 @default.
- W323252210 hasConcept C87874733 @default.
- W323252210 hasConceptScore W323252210C103796816 @default.
- W323252210 hasConceptScore W323252210C104317684 @default.
- W323252210 hasConceptScore W323252210C111829193 @default.
- W323252210 hasConceptScore W323252210C121608353 @default.
- W323252210 hasConceptScore W323252210C126322002 @default.
- W323252210 hasConceptScore W323252210C150194340 @default.
- W323252210 hasConceptScore W323252210C169760540 @default.
- W323252210 hasConceptScore W323252210C194583182 @default.
- W323252210 hasConceptScore W323252210C205003668 @default.
- W323252210 hasConceptScore W323252210C2777093970 @default.
- W323252210 hasConceptScore W323252210C2778042024 @default.
- W323252210 hasConceptScore W323252210C2779134260 @default.
- W323252210 hasConceptScore W323252210C2780192828 @default.
- W323252210 hasConceptScore W323252210C3008058167 @default.
- W323252210 hasConceptScore W323252210C36823959 @default.
- W323252210 hasConceptScore W323252210C502942594 @default.
- W323252210 hasConceptScore W323252210C524204448 @default.
- W323252210 hasConceptScore W323252210C54355233 @default.
- W323252210 hasConceptScore W323252210C555283112 @default.
- W323252210 hasConceptScore W323252210C71924100 @default.
- W323252210 hasConceptScore W323252210C81350143 @default.
- W323252210 hasConceptScore W323252210C86803240 @default.
- W323252210 hasConceptScore W323252210C87874733 @default.
- W323252210 hasLocation W3232522101 @default.
- W323252210 hasOpenAccess W323252210 @default.
- W323252210 hasPrimaryLocation W3232522101 @default.
- W323252210 hasRelatedWork W1576842662 @default.
- W323252210 hasRelatedWork W1588212060 @default.
- W323252210 hasRelatedWork W1829675031 @default.
- W323252210 hasRelatedWork W1936009905 @default.
- W323252210 hasRelatedWork W1979564952 @default.
- W323252210 hasRelatedWork W2015348126 @default.
- W323252210 hasRelatedWork W2045698719 @default.
- W323252210 hasRelatedWork W2063078051 @default.
- W323252210 hasRelatedWork W2064555088 @default.
- W323252210 hasRelatedWork W2099503871 @default.
- W323252210 hasRelatedWork W2118842644 @default.
- W323252210 hasRelatedWork W2165093251 @default.
- W323252210 hasRelatedWork W2166932579 @default.
- W323252210 hasRelatedWork W2338357991 @default.
- W323252210 hasRelatedWork W2792426012 @default.
- W323252210 hasRelatedWork W2895130262 @default.
- W323252210 hasRelatedWork W2901534288 @default.
- W323252210 hasRelatedWork W2955424070 @default.
- W323252210 hasRelatedWork W3008961309 @default.
- W323252210 hasRelatedWork W3130920699 @default.
- W323252210 isParatext "false" @default.
- W323252210 isRetracted "false" @default.
- W323252210 magId "323252210" @default.
- W323252210 workType "report" @default.