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• W323458476 startingPage "629" @default.
• W323458476 abstract "The use of laboratory tests has greatly enhanced the ability to diagnose systemic lupus erythematosus (SLE) and related disorders. Tests such as the antinuclear antibody (ANA) test and tests for antiphospholipid antibodies have been incorporated into the diagnosis of SLE. The clinical utility of antinucleosome-specific autoantibodies remains undefined, as their sensitivity, specificity, and association with particular manifestations of SLE remain undefined. Nevertheless, these antibodies are a source of interest because they may have a role in the pathogenesis of autoantibody production in SLE. Anti-hnRNP antibodies have limited utility in the diagnosis of connective tissue diseases as they are found at significant levels in multiple disorders and their presence appears to correlate highly with other specific antibodies (such as anti-Sm antibodies). As far as the anti-PCNA antibody test is concerned, despite its high specificity, the test has limited clinical utility because of its very low sensitivity. However, it is important to remember when using these tests, as with any other test in a clinical setting, to consider their sensitivity, specificity, and predictive value. In addition, laboratory tests are often used to assess the activity of SLE. In this respect, serum complement levels, anti-double-stranded (ds)DNA, and acute-phase reactants have often proved to be useful. Laboratory tests are also used as in any disease to assess organ involvement and function (e.g., renal function). Finally, laboratory tests are often used to evaluate the patient's response to therapy, and again many tests have been useful in this respect." @default.
• W323458476 created "2016-06-24" @default.
• W323458476 creator A5000782257 @default.
• W323458476 date "2011-01-01" @default.
• W323458476 modified "2023-09-27" @default.
• W323458476 title "Laboratory Evaluation of Patients with Systemic Lupus Erythematosus" @default.
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