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- W3236112 abstract "Transient receptor potential canonical 7 (TRPC7) channel is the seventh member of the mammalian TRPC channel family. TRPC7 mRNA, protein, and channel activity have been detected in many tissues and organs from the mouse, rat, and human. TRPC7 has high sequence homology with TRPC3 and TRPC6, and all three channels are activated by membrane receptors that couple to isoforms of phospholipase C (PLC) and mediate non-selective cation currents. TRPC7, along with TRPC3 and TRPC6, can be activated by direct exogenous application of diacylglycerol (DAG) analogues and by pharmacological maneuvers that increase endogenous DAG in cells. TRPC7 shows distinct properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca2+ and by protein kinase C. TRPC7 can form heteromultimers with TRPC3 and TRPC6. Although TRPC7 remains one of the least studied TRPC channel, its role in various cell types and physiological and pathophysiological conditions is beginning to emerge." @default.
- W3236112 created "2016-06-24" @default.
- W3236112 creator A5061372270 @default.
- W3236112 creator A5063808923 @default.
- W3236112 date "2014-01-01" @default.
- W3236112 modified "2023-09-23" @default.
- W3236112 title "Transient Receptor Potential Canonical 7: A Diacylglycerol-Activated Non-selective Cation Channel" @default.
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- W3236112 doi "https://doi.org/10.1007/978-3-642-54215-2_8" @default.
- W3236112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4838195" @default.
- W3236112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24756707" @default.
- W3236112 hasPublicationYear "2014" @default.
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