FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W32376936> ?p ?o ?g. }

• W32376936 abstract "The human hairy skin is innervated by a very ancient system of slow-conducting low-threshold mechanoreceptors termed C-tactile fibres (CTs). Intriguingly, even the existence of CTs in the distal limbs (non-hairy/glabrous skin) remains to be established, let alone their functional significance in the neural system. In this thesis, we examined the function of CTs through the prism of pain and its multifarious expressions, in particular touch-evoked pain (allodynia). In Paper I, we showed that the deep somatic pain generated by infusion of hypertonic saline (HS: 5%) into the tibialis anterior muscle is enhanced by concurrent application of vibration (200 Hz200 μm) and brushing (1.0 and 3.0 cm s) to the overlying hairy skin. In Paper II, we demonstrated that a comparable expression of allodynia elicits when vibration and brushing are applied across skin types and spinal segments – glabrous skin of fingers and hairy skin of dorsal forearm – during HS-infusion into the flexor carpi ulnaris muscle. In Paper III, we showed that vibration evokes pain/allodynia following eccentric exercise-induced muscle soreness (no resting pain). Furthermore, a cognate expression of touch-evoked allodynia was observed in a clinical subject with activity-triggered heel-pain without exposure to eccentric exercise. In Paper IV, we demonstrated that, in the presence of HS-induced cutaneous pain, the application of vibration to an adjacent region of skin generates allodynia. In all four papers, the vibrationand brush-evoked allodynia persisted following conduction block of myelinated afferents by compression. In contrast, the effect was abolished during conduction block of cutaneous C fibres by injecting a local anaesthetic into the skin stimulation by vibration. Collectively these psychophysical observations provide the first human evidence that CTs arising from hairy skin, and their functional counterparts in glabrous skin, contribute to mechanical allodynia. This phenomenon appears to be reproducible in perceptible (HS-induced), imperceptible (exercise-induced) and pathological pain-states." @default.
• W32376936 created "2016-06-24" @default.
• W32376936 creator A5003049985 @default.
• W32376936 date "2012-01-01" @default.
• W32376936 modified "2023-09-27" @default.
• W32376936 title "LOW-THRESHOLD UNMYELINATED MECHANORECEPTORS: A NOVEL SUBSTRATE OF ALLODYNIA IN HUMAN SKIN" @default.
• W32376936 cites W134382380 @default.
• W32376936 cites W1502904746 @default.
• W32376936 cites W1514349633 @default.
• W32376936 cites W1519911287 @default.
• W32376936 cites W1525139037 @default.
• W32376936 cites W1607862065 @default.
• W32376936 cites W174656537 @default.
• W32376936 cites W1824892726 @default.
• W32376936 cites W1845054049 @default.
• W32376936 cites W1869612208 @default.
• W32376936 cites W1904625121 @default.
• W32376936 cites W1949260838 @default.
• W32376936 cites W1964055928 @default.
• W32376936 cites W1964670356 @default.
• W32376936 cites W1965223467 @default.
• W32376936 cites W1968181716 @default.
• W32376936 cites W1971690345 @default.
• W32376936 cites W1972451937 @default.
• W32376936 cites W1974153818 @default.
• W32376936 cites W1975226770 @default.
• W32376936 cites W1975312927 @default.
• W32376936 cites W1978902440 @default.
• W32376936 cites W1979815637 @default.
• W32376936 cites W1981887875 @default.
• W32376936 cites W1984045322 @default.
• W32376936 cites W1984461996 @default.
• W32376936 cites W1985144092 @default.
• W32376936 cites W1988059170 @default.
• W32376936 cites W1988548196 @default.
• W32376936 cites W1989437705 @default.
• W32376936 cites W1990832845 @default.
• W32376936 cites W1991540821 @default.
• W32376936 cites W1991550485 @default.
• W32376936 cites W1994618304 @default.
• W32376936 cites W1995277206 @default.
• W32376936 cites W1996108985 @default.
• W32376936 cites W1996109821 @default.
• W32376936 cites W1996371627 @default.
• W32376936 cites W1996599584 @default.
• W32376936 cites W1998272805 @default.
• W32376936 cites W2001190920 @default.
• W32376936 cites W2001234197 @default.
• W32376936 cites W2001333725 @default.
• W32376936 cites W2001461949 @default.
• W32376936 cites W2002422568 @default.
• W32376936 cites W2002522691 @default.
• W32376936 cites W2003269271 @default.
• W32376936 cites W2003542915 @default.
• W32376936 cites W2004518294 @default.
• W32376936 cites W2004770854 @default.
• W32376936 cites W2005116196 @default.
• W32376936 cites W2005273426 @default.
• W32376936 cites W2007266071 @default.
• W32376936 cites W2009401184 @default.
• W32376936 cites W2012619381 @default.
• W32376936 cites W2013327239 @default.
• W32376936 cites W2017612254 @default.
• W32376936 cites W2018638145 @default.
• W32376936 cites W2020180345 @default.
• W32376936 cites W2021633509 @default.
• W32376936 cites W2022898812 @default.
• W32376936 cites W2023906412 @default.
• W32376936 cites W2023983161 @default.
• W32376936 cites W2024928397 @default.
• W32376936 cites W2028393475 @default.
• W32376936 cites W2028600796 @default.
• W32376936 cites W2028941930 @default.
• W32376936 cites W2029474733 @default.
• W32376936 cites W2029739634 @default.
• W32376936 cites W2031811175 @default.
• W32376936 cites W2032947987 @default.
• W32376936 cites W2036116094 @default.
• W32376936 cites W2036127013 @default.
• W32376936 cites W2038093917 @default.
• W32376936 cites W2038287202 @default.
• W32376936 cites W2038402091 @default.
• W32376936 cites W2041070362 @default.
• W32376936 cites W2041458853 @default.
• W32376936 cites W2043373262 @default.
• W32376936 cites W2047010161 @default.
• W32376936 cites W2047757182 @default.
• W32376936 cites W2048886109 @default.
• W32376936 cites W2050369461 @default.
• W32376936 cites W2050725524 @default.
• W32376936 cites W2054041622 @default.
• W32376936 cites W2054665449 @default.
• W32376936 cites W2059579731 @default.
• W32376936 cites W2061435810 @default.
• W32376936 cites W2061466600 @default.
• W32376936 cites W2061874226 @default.
• W32376936 cites W2062158238 @default.
• W32376936 cites W2063376082 @default.
• W32376936 cites W2063961904 @default.
• W32376936 cites W2064249042 @default.

• next