Matches in SemOpenAlex for { <https://semopenalex.org/work/W32459920> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W32459920 abstract "The central challenge of lymphatic research is to relate what is known about contractile lymphangions to the formation and resolution of edema. Because lymphatic system function emerges from the complex interaction of lymphangions that act both like blood vessels and cardiac ventricles, we have developed two complementary modeling approaches. First, we developed a lymphangion model that merges classical hemodynamics with the time-varying elastance model of ventricles. By theoretically connecting lymphangions, we discovered that lymphangion structure optimizes stroke work, and lymphatic networks optimize lymph flow. Second, we developed an organ-level compartment model that incorporates microvascular water and protein flux, interstitial storage capacity, and lymphatic drainage. This approach revealed that interstitial volume is a simple function of microvascular permeability, interstitial compliance, and the effective lymphatic resistance, RL. Merging these two modeling approaches provides a critical link between local lymphangion properties and global lymphatic function characterized by RL. Multiscale modeling thus provides a strategy to translate basic lymphatic biology to clinical edema research." @default.
- W32459920 created "2016-06-24" @default.
- W32459920 creator A5000669454 @default.
- W32459920 creator A5012678106 @default.
- W32459920 creator A5014212911 @default.
- W32459920 creator A5014572356 @default.
- W32459920 creator A5062044346 @default.
- W32459920 creator A5088766618 @default.
- W32459920 date "2009-04-01" @default.
- W32459920 modified "2023-10-18" @default.
- W32459920 title "Multiscale modeling of the lymphatic system relates lymphangion properties to edema formation and resolution" @default.
- W32459920 doi "https://doi.org/10.1096/fasebj.23.1_supplement.764.10" @default.
- W32459920 hasPublicationYear "2009" @default.
- W32459920 type Work @default.
- W32459920 sameAs 32459920 @default.
- W32459920 citedByCount "0" @default.
- W32459920 crossrefType "journal-article" @default.
- W32459920 hasAuthorship W32459920A5000669454 @default.
- W32459920 hasAuthorship W32459920A5012678106 @default.
- W32459920 hasAuthorship W32459920A5014212911 @default.
- W32459920 hasAuthorship W32459920A5014572356 @default.
- W32459920 hasAuthorship W32459920A5062044346 @default.
- W32459920 hasAuthorship W32459920A5088766618 @default.
- W32459920 hasConcept C121608353 @default.
- W32459920 hasConcept C126322002 @default.
- W32459920 hasConcept C142724271 @default.
- W32459920 hasConcept C181152851 @default.
- W32459920 hasConcept C2779013556 @default.
- W32459920 hasConcept C2779720271 @default.
- W32459920 hasConcept C2779822359 @default.
- W32459920 hasConcept C2780886150 @default.
- W32459920 hasConcept C2780965494 @default.
- W32459920 hasConcept C2781392513 @default.
- W32459920 hasConcept C2910366181 @default.
- W32459920 hasConcept C41008148 @default.
- W32459920 hasConcept C530470458 @default.
- W32459920 hasConcept C71924100 @default.
- W32459920 hasConceptScore W32459920C121608353 @default.
- W32459920 hasConceptScore W32459920C126322002 @default.
- W32459920 hasConceptScore W32459920C142724271 @default.
- W32459920 hasConceptScore W32459920C181152851 @default.
- W32459920 hasConceptScore W32459920C2779013556 @default.
- W32459920 hasConceptScore W32459920C2779720271 @default.
- W32459920 hasConceptScore W32459920C2779822359 @default.
- W32459920 hasConceptScore W32459920C2780886150 @default.
- W32459920 hasConceptScore W32459920C2780965494 @default.
- W32459920 hasConceptScore W32459920C2781392513 @default.
- W32459920 hasConceptScore W32459920C2910366181 @default.
- W32459920 hasConceptScore W32459920C41008148 @default.
- W32459920 hasConceptScore W32459920C530470458 @default.
- W32459920 hasConceptScore W32459920C71924100 @default.
- W32459920 hasIssue "S1" @default.
- W32459920 hasLocation W324599201 @default.
- W32459920 hasOpenAccess W32459920 @default.
- W32459920 hasPrimaryLocation W324599201 @default.
- W32459920 hasRelatedWork W187773706 @default.
- W32459920 hasRelatedWork W1985853631 @default.
- W32459920 hasRelatedWork W2009202976 @default.
- W32459920 hasRelatedWork W2158627817 @default.
- W32459920 hasRelatedWork W2410416798 @default.
- W32459920 hasRelatedWork W2783566231 @default.
- W32459920 hasRelatedWork W4214527697 @default.
- W32459920 hasRelatedWork W4361242121 @default.
- W32459920 hasRelatedWork W4361261109 @default.
- W32459920 hasRelatedWork W52738963 @default.
- W32459920 hasVolume "23" @default.
- W32459920 isParatext "false" @default.
- W32459920 isRetracted "false" @default.
- W32459920 magId "32459920" @default.
- W32459920 workType "article" @default.