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- W32461060 abstract "AIM: To investigate the expression of RhoC gene inhepatocellular carcinoma (HCC) and to evaluate therelationship between RhoC gene expression and invasionand metastasis of HCC.METHODS: mRNA expression level of RhoC gene wasexamined by reverse transcription-polymerase chain reaction(RT-PCR) in 25 cases of HCC and para-cancerous normalliver tissues. In addition, mutation of RhoC gene wasexamined by polymerase chain reaction-single strandconformational polymorphism (PCR-SSCP).RESULTS: The mRNA expression levels of RhoC in tumortissues were significantly higher than those in para-cancerousnormal liver tissues (1.8±1.1 vs 1.0±0.7, P＜0.01). Themetastatic lesions outside of liver also showed significantlyhigher RhoC mRNA levels than corresponding tumor tissuesin liver (3.3±0.5 vs2.0±0.7, P＜0.01). There were significantassociations between RhoC gene expression and certainclinical and pathological findings, including celldifferentiation, vein invasion, number of tumor nodes andmetastatic lesions. Mutation of RhoC gene was not foundby PCR-SSCP.CONCLUSION: The RhoC gene may be related to malignanttransformation and development of HCC and may play animportant role in the invasion and metastasis of HCC byoverexpression but not mutation." @default.
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- W32461060 date "2003-01-01" @default.
- W32461060 modified "2023-09-28" @default.
- W32461060 title "Expression and significance of RhoC gene in hepatocellular carcinoma" @default.
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