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- W324677734 abstract "Publisher Summary This chapter discusses a third mechanism of immune tolerance by which self-reactive effector T cells can be eliminated on encountering tissue cells that are devoid of costimulatory activity. Clonal deletion is a successful mechanism for eliminating T cells whose receptors recognize self-antigens expressed by bone marrow-derived antigen-presenting cells (APCs). The best data at present come from studies of T-cell responses to artificially introduced tissue-specific antigens. Hammerling et al . have now provided some evidence that shows clonal deletion caused by tissue-specific antigens. The chapter presents a study on activation-induced death of cloned effector T cells. The fate of effector T cells is determined by co-stimulatory activity of the cells they react with; effector T cells can be further expanded if antigens are presented by cells with co-stimulatory activity. However, these same T cells are deleted if they interact with antigens expressed on cells that lack co-stimulatory activity." @default.
- W324677734 created "2016-06-24" @default.
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- W324677734 date "1993-01-01" @default.
- W324677734 modified "2023-10-18" @default.
- W324677734 title "Activation-Induced Cell Death of Effector T Cells: A Third Mechanism of Immune Tolerance" @default.
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- W324677734 doi "https://doi.org/10.1016/b978-0-12-053750-1.50018-0" @default.
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