FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W324771279> ?p ?o ?g. }

• W324771279 endingPage "372" @default.
• W324771279 startingPage "364" @default.
• W324771279 abstract "Morphine elicits a paradoxical state of increased pain sensitivity, known as morphine-induced hyperalgesia (MIH), which complicates its clinical efficacy. We have previously shown that systemic injections of N-methyl-d-aspartate receptor (NMDAR) and melanocortin-1 receptor (MC1R) antagonists sex-dependently reverse MIH during morphine infusion (40mg/kg/24h) in male and female mice, respectively. This qualitative sex difference is ovarian hormone dependent, as NMDAR antagonists reverse MIH in ovariectomized females but are rendered ineffective following progesterone injection in OVX mice. Here, we utilized intrathecal and intracerebroventricular injection paradigms to assess the contribution of spinal and supraspinal receptors to this sex difference in male and female CD-1 mice. Specifically, we injected NMDAR and MC1R selective antagonists, MK-801 and MSG606 respectively, during morphine infusion. Results illustrated that both spinal and supraspinal MK-801 and MSG606 selectively reversed MIH in males and females, respectively, during morphine infusion. Furthermore, while MK-801 reversed MIH in ovariectomized (OVX) females, MSG606 was most effective in doing so in this same group following an acute subcutaneous progesterone injection. The present studies thus indicate that both spinal and supraspinal NMDARs and MC1Rs underlie the qualitative sex difference observed during morphine infusion in mice, and that the receptors in these loci are also sensitive to sex steroidal modulation." @default.
• W324771279 created "2016-06-24" @default.
• W324771279 creator A5022760863 @default.
• W324771279 creator A5030176843 @default.
• W324771279 creator A5072903338 @default.
• W324771279 creator A5090413498 @default.
• W324771279 date "2015-08-01" @default.
• W324771279 modified "2023-10-18" @default.
• W324771279 title "Spinal and supraspinal N-methyl-d-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia" @default.
• W324771279 cites W1966090527 @default.
• W324771279 cites W1976448473 @default.
• W324771279 cites W1979514882 @default.
• W324771279 cites W1985082623 @default.
• W324771279 cites W1988450549 @default.
• W324771279 cites W1990990356 @default.
• W324771279 cites W1991601559 @default.
• W324771279 cites W1993672558 @default.
• W324771279 cites W1997967560 @default.
• W324771279 cites W2001724515 @default.
• W324771279 cites W2004551214 @default.
• W324771279 cites W2006442862 @default.
• W324771279 cites W2007908570 @default.
• W324771279 cites W2010271493 @default.
• W324771279 cites W2011374164 @default.
• W324771279 cites W2012735567 @default.
• W324771279 cites W2013924802 @default.
• W324771279 cites W2014793146 @default.
• W324771279 cites W2020651500 @default.
• W324771279 cites W2023035230 @default.
• W324771279 cites W2024084892 @default.
• W324771279 cites W2027642651 @default.
• W324771279 cites W2028500739 @default.
• W324771279 cites W2029479481 @default.
• W324771279 cites W2032141855 @default.
• W324771279 cites W2033525233 @default.
• W324771279 cites W2033641234 @default.
• W324771279 cites W2034102455 @default.
• W324771279 cites W2044516026 @default.
• W324771279 cites W2044994676 @default.
• W324771279 cites W2052495267 @default.
• W324771279 cites W2054355243 @default.
• W324771279 cites W2061411565 @default.
• W324771279 cites W2065361276 @default.
• W324771279 cites W2066362290 @default.
• W324771279 cites W2068237121 @default.
• W324771279 cites W2072388030 @default.
• W324771279 cites W2073321097 @default.
• W324771279 cites W2076150851 @default.
• W324771279 cites W2077483410 @default.
• W324771279 cites W2078442495 @default.
• W324771279 cites W2078959483 @default.
• W324771279 cites W2080221942 @default.
• W324771279 cites W2083142828 @default.
• W324771279 cites W2086356035 @default.
• W324771279 cites W2088637181 @default.
• W324771279 cites W2091061257 @default.
• W324771279 cites W2093481212 @default.
• W324771279 cites W2099105393 @default.
• W324771279 cites W2115393043 @default.
• W324771279 cites W2136961324 @default.
• W324771279 cites W2138512124 @default.
• W324771279 cites W2155133695 @default.
• W324771279 cites W2156989552 @default.
• W324771279 cites W2160308384 @default.
• W324771279 cites W2160354010 @default.
• W324771279 cites W2166622977 @default.
• W324771279 doi "https://doi.org/10.1016/j.physbeh.2015.05.006" @default.
• W324771279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25982086" @default.
• W324771279 hasPublicationYear "2015" @default.
• W324771279 type Work @default.
• W324771279 sameAs 324771279 @default.
• W324771279 citedByCount "29" @default.
• W324771279 countsByYear W3247712792015 @default.
• W324771279 countsByYear W3247712792016 @default.
• W324771279 countsByYear W3247712792017 @default.
• W324771279 countsByYear W3247712792018 @default.
• W324771279 countsByYear W3247712792019 @default.
• W324771279 countsByYear W3247712792020 @default.
• W324771279 countsByYear W3247712792021 @default.
• W324771279 countsByYear W3247712792022 @default.
• W324771279 countsByYear W3247712792023 @default.
• W324771279 crossrefType "journal-article" @default.
• W324771279 hasAuthorship W324771279A5022760863 @default.
• W324771279 hasAuthorship W324771279A5030176843 @default.
• W324771279 hasAuthorship W324771279A5072903338 @default.
• W324771279 hasAuthorship W324771279A5090413498 @default.
• W324771279 hasConcept C126322002 @default.
• W324771279 hasConcept C134018914 @default.
• W324771279 hasConcept C15490471 @default.
• W324771279 hasConcept C170493617 @default.
• W324771279 hasConcept C2777389121 @default.
• W324771279 hasConcept C2778938600 @default.
• W324771279 hasConcept C2779245659 @default.
• W324771279 hasConcept C2779993316 @default.
• W324771279 hasConcept C67018056 @default.
• W324771279 hasConcept C71315377 @default.
• W324771279 hasConcept C71924100 @default.
• W324771279 hasConcept C8264082 @default.

• next