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- W324831251 abstract "Acetylcholine (ACh) output from cortical slices incubated in Krebs solution was quantified by bioassay. The calcium ionophores BrX-537A and A23187 enhanced ACh output; BrX-S37A exerted its maximal effect, a 6-fold increase, at a concentration of 1.8 pM; A23187 caused a 3-fold increase at 58 μM. Raising Mg2+ to 9.3 mM doubled the peak effect of both ionophores. In Mg-free media the effect of both ionophores was reduced but the spontaneous ACh output was larger. In Ca-free media the effect of A23187 was abolished, and that of BrX-S37A strongly reduced even in the presence of 9.3 mM Mg2+. BrX-537A exerted some effect also when EDTA was added to the Ca-free medium. Raising Ca2+ to 5 mM increased the spontaneous ACh output but decreased the ionophore effect. Hyoscine (0.26 μM), but not the ionophores, further enhanced ACh output stimulated by KCI (25 mM). Hyoscine did not enhance ACh output stimulated by the ionophores The addition of hemicholinium-3 (0.01 mM) did not abolish the effect of the ionophores but suppressed the enhancing action of Mg2+ It is concluded that A23187 stimulates ACh output by transporting extracellular Ca2+into cholinergic nerve endings. The effect of BrX-537A does not depend only on Ca2+. The magnitude of the effect of both ionophores is modulated by ions and drugs affecting the synthesis and spontaneous output of ACh." @default.
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- W324831251 date "1979-01-01" @default.
- W324831251 modified "2023-09-27" @default.
- W324831251 title "Effect of Calcium Ionophores on Acetylcholine Output from Rat Brain Slices" @default.
- W324831251 doi "https://doi.org/10.1016/s0079-6123(08)64684-1" @default.
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