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• W324842942 abstract "Over the last decades, the high throughput toolbox of neurobiologists to measure molecular changes in the brain has grown rapidly. The molecular effects of induced genetic mutations or pharmacological treatment relevant to psychiatric disorders can now be studied on a large scale. In contrast, to investigate the behavioral consequences of genetic mutations or pharmacological treatment, researchers rely on multiple stand-alone tests, each of which taxes a specific aspect of a different behavioral domain. It is clear that these conventional stand-alone tests give highly valuable detailed information about specific psychological constructs. However, for the purpose of phenotyping larger numbers of novel mutants or novel pharmaceuticals, performing a battery of these conventional tests has two major drawbacks. First of all, performing a battery of tests requires a substantial amount of time and resources. Secondly, it has proven to be difficult to reproducibly measure behavioral effects in different laboratories, especially subtle ones [1]. This difficulty in reproducibility may partly be due to a multitude of humananimal interactions required for these behavioral tests. Therefore, automation may be a way of reducing the required amount of time and resources involved with behavioral phenotyping. In addition, automation will circumvent humananimal interactions, and thereby holds the promise to increase reproducibility of behavioral results across laboratories. The development of automated phenotyping strategies has only started recently, for instance using automated home cage observations[2]. More research is needed, especially to increase throughput and to investigate the sensitivity and reproducibility of these automated behavioral tests. Within the framework of the Dutch Neuro-Bsik Mouse Phenomics project, an automated high throughput screening protocol was developed, consisting of an automated home cage environment (PhenoTyper®) and separate home cages equipped with running wheels. Neuro-Bsik Mouse Phenomics is a Dutch consortium of 11 academic research groups and two companies. The consortium aims to contribute to the understanding of brain disorders by developing novel mouse models for brain disorders. These models will be initially identified using the automated high throughput screening protocol to analyze mouse behavior and subsequently be analyzed in depth at different levels of complexity using the specific expertise of each of the academic partners. For the aims of the consortium, it is essential to investigate whether the developed automated high throughput screening protocol can discriminate mouse behavior with sufficient resolution, e.g. mutant from wild type mice or specific behavioral differences between common inbred lines of mice. Secondly, if differences in behavior between genotypes are detected, the high throughput screen should indicate in which behavioral domain (e.g. circadian rhythm, anxiety, learning) further in-depth analysis might be fruitful." @default.
• W324842942 created "2016-06-24" @default.
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• W324842942 date "2008-01-01" @default.
• W324842942 modified "2023-09-27" @default.
• W324842942 title "The PhenoTyper automated home cage environment as a high throughput tool to detect behavioral abnormalities in mutant mice" @default.
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