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- W324895917 abstract "Objectives: IgG4-related autoimmune pancreatitis (AIP) is a new clinical entity of pancreatic disorder. There are immunologic and histological abnormalities, including increased serum IgG4 levels and the infiltration of lymphocytes and IgG4-positive plasmacytes. However, the role of IgG4 is unclear. Recently, regulatory T cells (Tregs) were reported to contribute to the development of various autoimmune diseases as well as in B cell shifting to IgG4producing plasmacytes. For this report, we studied regulatory T cells in the pancreas by immunohistochemistory and ICOS+ Tregs and IL-10 producing cells in the peripheral blood lymphocytes by flowcytometry. Methods: We recruited 44 patients with IgG4-related AIP. For comparison, we recruited 37 patients with other pancreatic diseases and 27 healthy subjects as controls. We studied infiltrating cells in the pancreas by immunohistochemistry, and analyzed ICOS+ Tregs and IL-10+ Tregs in the peripheral blood by flow cytometry. Results: The ratio of Foxp3-positive cells to infiltrated mononuclear cells (Foxp3/Mono) in AIP patients (0.091 ± 0.023) was significantly higher than in patients with alcoholic chronic pancreatitis (0.012 ± 0.003; p<0.05). In AIP, Foxp3/Mono and IgG4/Mono were positively correlated (p<0.05; R =0.91). ICOS+ Tregs (%ICOS-positive Tregs of total Tregs) were significantly higher in AIP patients (3.45% ± 1.58%) than in the patients with other pancreatic diseases (alcoholic chronic pancreatitis; 1.71% ± 0.98%, idiopathic chronic pancreatitis; 1.80% ± 0.86%) and the healthy control group (1.57% ± 0.69%, p<0.05). IL-10+ Tregs were significantly higher in AIP patients than in the healthy control group. Conclusions: Increased quantities of ICOS+ Tregs may influence IgG4 production in IgG4-related AIP." @default.
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- W324895917 date "2011-05-01" @default.
- W324895917 modified "2023-10-18" @default.
- W324895917 title "The SRC Family Kinase, Yes, is Present in Pancreatic Acinar Cells and Activated by Numerous Gastrointestinal Hormones and Growth Factors" @default.
- W324895917 doi "https://doi.org/10.1016/s0016-5085(11)62959-4" @default.
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