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- W32529658 endingPage "63" @default.
- W32529658 startingPage "152" @default.
- W32529658 abstract "The ability of malignant cells to escape the constraint that normally regulate cell growth and differentiation has been a primary focus of attention for investigators of cancer cell biology. An outcome of this attention has been the discovery that the protein products of oncogenes play a role in the activation of growth signal pathways. A second outcome, possibly related to abnormal oncogene expression, has been the discovery that malignant cells frequently show an ability to regulate their own growth by the release of autocrine growth modulatory substances. Most important, the growth of certain malignant cell types has been shown to depend on autocrine growth circuits. A malignant tumor whose continued growth depends on the release of an autocrine growth factor may be vulnerable to treatment with specific receptor antagonists or immunoneutralizing antibodies designed to break the autocrine circuit. Information is rapidly emerging concerning autocrine growth factors in selected human solid tissue malignancy." @default.
- W32529658 created "2016-06-24" @default.
- W32529658 creator A5012428409 @default.
- W32529658 creator A5066577343 @default.
- W32529658 creator A5086687120 @default.
- W32529658 creator A5091680206 @default.
- W32529658 date "1991-08-01" @default.
- W32529658 modified "2023-09-25" @default.
- W32529658 title "Autocrine growth factors and solid tumor malignancy." @default.
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