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- W325492742 abstract "This chapter discusses self-tolerance. T-cell receptor (TCR) peptide immunization can modulate the immune response to a self-antigen in different ways depending on factors. In some instances, the same peptide will result in either suppression or enhancement. If downregulation is mediated through activated regulatory T cells, then it is not unreasonable that elimination of such cells might result in upregulation of an anti-self response. There are different classes of interaction. The response to a nonself-antigen leads to an immunity that is clearly delimited and quickly subsides, presumably when the antigen disappears. The response to a self-antigen given in adjuvant also leads to a delimited, acute response that also diminishes presumably when the injected antigen disappears. In this case, one of the antigens, the TCR, which is represented on circulating T cells in the periphery of the animal and is continually replenished, is not eliminated and can chronically restimulate the T cells." @default.
- W325492742 created "2016-06-24" @default.
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- W325492742 date "1993-01-01" @default.
- W325492742 modified "2023-10-18" @default.
- W325492742 title "Tolerance to Self: A Delicate Balance" @default.
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- W325492742 doi "https://doi.org/10.1016/b978-0-12-053750-1.50023-4" @default.
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