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- W325804585 abstract "Mechanotransduction is the process of translating mechanical stimulation into cellular reaction, by which the live tissues adapt to mechanical environment all around and obtain extensive physiological functions. Mechanotransduction is involved in many important physiololgical processes of many kinds of tissues and plays an important role in the morphological, developmental and functional states of cells in vivo and in vitro. This paper describes the influence of FAK, RhoA/ROCK and mechanical stretch on the morphology of hMSCs, and the role of FAK and RhoA/ROCK in the mechanotransduction mechanism of tenogenic differentiation of hMSCs. We found that FAK and RhoA/ROCK are important for hMSCs to maintain the fibroblast-like morphology. We also show that FAK and RhoA/ROCK are critical to the mechanical stretch-induced tenogenic differentiation of hMSCs." @default.
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- W325804585 date "2010-01-01" @default.
- W325804585 modified "2023-10-16" @default.
- W325804585 title "T0201-2-5 Study on the mechanostransduction mechanism of tenogenic differentiation of human mesenchymal stem cells" @default.
- W325804585 doi "https://doi.org/10.1299/jsmemecjo.2010.8.0_151" @default.
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