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- W326858875 abstract "Histamine catabolism in man proceeds via two main enzymatic pathways: (1) the oxidative deamination of histamine to imidazole acetic acid proceeds via the enzyme histaminase (diamine oxidase) and (2) N -methylation of histamine to methylhistamine via histamine O -methyl transferase. The number of nanomole converted is calculated by subtracting the counts per minute for the enzyme assay from the blank. While both guinea pig brain and rat kidney are highly active sources of this enzyme, the latter may be a more active and specific source of histamine methyltransferase. The latter enzyme activity is measured by its ability to form the methylated metabolites of histamine in the presence of radio-labeled methyl donor. The assay is performed in a mixture that contains an inhibitor of histaminase to prevent the catabolism of histamine by the alternative mechanism. The assay is applicable to the study of mononuclear phagocytes from all species." @default.
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- W326858875 date "1981-01-01" @default.
- W326858875 modified "2023-09-26" @default.
- W326858875 title "HISTAMINE-O-METHYLTRANSFERASE" @default.
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- W326858875 doi "https://doi.org/10.1016/b978-0-12-044220-1.50053-2" @default.
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