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- W327156816 abstract "Despite the well-established role of hypoxia in cancer biology, the literature on its effects on endometrial cancer is scarce; it mainly refers to experimental settings rather than patient-derived results. Herein, an overview of the hypoxia inducible factor 1α (HIF-1α) biology, focusing on endometrial cancer, is presented. The molecular mechanisms possibly involved in endometrial cancer progression are presented, followed by a systematic approach to the current literature on immunohistochemistry evaluation of HIF-1α expression in endometrial carcinoma. Since no consensus has been made regarding HIF-1α evaluation, the evidence of possible involvement of HIF-1α in endometrial carcinoma prognosis is weak. After a consensus has been made, properly powered studies may be able to clarify whether HIF-1α can act as a prognosticator in endometrial carcinoma." @default.
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- W327156816 date "2012-10-01" @default.
- W327156816 modified "2023-09-29" @default.
- W327156816 title "Hypoxia-induced factor-1α in endometrial carcinoma: a mini-review of current evidence." @default.
- W327156816 doi "https://doi.org/10.14670/hh-27.1247" @default.
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