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- W327321738 abstract "Influenza virus-induced apoptosis in A549 cells was observed by Annexin V/PI and Hoechst 33258 labeling method,and meanwhile protein expression of MDM2,p53 and its downstream p21 were detected by western blot analysis.The results showed that A549 cells exhibited typical characteristics of apoptosis,and percentage of cell death obviously increased after the treatment with 100 TCID50/0.1mL influenza virus.Furthermore,MDM2 expression decreased,both p53 expression and its phosphorylation elevated,and its downstream p21 also activated during influenza virus-induced apoptosis.Taken together,p53 and MDM2 were synergistically involved in influenza virus-induced A549 cells apoptosis." @default.
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- W327321738 date "2009-01-01" @default.
- W327321738 modified "2023-09-23" @default.
- W327321738 title "Influences on MDM2 and p53 in influenza virus-induced apoptosis in human A549 cells." @default.
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