Matches in SemOpenAlex for { <https://semopenalex.org/work/W327562175> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W327562175 endingPage "8293" @default.
- W327562175 startingPage "8287" @default.
- W327562175 abstract "RABEX-5 has been studied in various solid tumors, but its role in combined small cell lung cancer (C-SCLC) remains unknown. This study aimed to investigate the expression, the potential relevance to clinicopathological characters and prognostic significance of RABEX-5 in patients with C-SCLC. Fifty-two C-SCLC patients who received radical surgery were enrolled in our study. The clinicalpathological data and survival time were reviewed. The mRNA and protein expression of RABEX-5 from the paired tumor tissues and adjacent normal tissues were determined, and its relationship with clinicalpathological variables and prognosis was analyzed. Univariate and multivariate analyses were performed to investigate the prognostic significance of RABEX-5 for C-SCLC. The mRNA and protein expression level of RABEX-5 was significantly elevated in C-SCLC tissues. The increased RABEX-5 protein expression was correlated with clinical stage (p = 0.011) and tumor recurrence (p = 0.006). The median OS and DFS was significantly shorter in the high RABEX-5 expression group compared to low RABEX-5 expression group (OS: 12.0 vs. 21.7 months, p = 0.014; DFS: 6.7 vs. 11.8 months, p = 0.005). Multivariate Cox analysis indicated that high RABEX-5 protein expression was an independent prognostic factor for OS and DFS (p < 0.001). RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for C-SCLC, which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients." @default.
- W327562175 created "2016-06-24" @default.
- W327562175 creator A5000493406 @default.
- W327562175 creator A5023472881 @default.
- W327562175 creator A5053156998 @default.
- W327562175 creator A5070854145 @default.
- W327562175 creator A5075428074 @default.
- W327562175 date "2015-05-23" @default.
- W327562175 modified "2023-10-18" @default.
- W327562175 title "Elevated RABEX-5 protein expression predicts poor prognosis in combined small cell lung cancer" @default.
- W327562175 cites W1973831137 @default.
- W327562175 cites W1985597927 @default.
- W327562175 cites W1990940222 @default.
- W327562175 cites W2001644579 @default.
- W327562175 cites W2008680914 @default.
- W327562175 cites W2013706690 @default.
- W327562175 cites W2017829359 @default.
- W327562175 cites W2019122150 @default.
- W327562175 cites W2070521247 @default.
- W327562175 cites W2080923301 @default.
- W327562175 cites W2098541285 @default.
- W327562175 cites W2099203056 @default.
- W327562175 cites W2107087407 @default.
- W327562175 cites W2132458567 @default.
- W327562175 cites W2140074985 @default.
- W327562175 cites W2148889205 @default.
- W327562175 cites W2150968053 @default.
- W327562175 cites W2158123283 @default.
- W327562175 cites W2169411097 @default.
- W327562175 cites W2419401359 @default.
- W327562175 cites W4242747250 @default.
- W327562175 cites W4376453862 @default.
- W327562175 doi "https://doi.org/10.1007/s13277-015-3562-4" @default.
- W327562175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26002576" @default.
- W327562175 hasPublicationYear "2015" @default.
- W327562175 type Work @default.
- W327562175 sameAs 327562175 @default.
- W327562175 citedByCount "3" @default.
- W327562175 countsByYear W3275621752016 @default.
- W327562175 countsByYear W3275621752018 @default.
- W327562175 countsByYear W3275621752020 @default.
- W327562175 crossrefType "journal-article" @default.
- W327562175 hasAuthorship W327562175A5000493406 @default.
- W327562175 hasAuthorship W327562175A5023472881 @default.
- W327562175 hasAuthorship W327562175A5053156998 @default.
- W327562175 hasAuthorship W327562175A5070854145 @default.
- W327562175 hasAuthorship W327562175A5075428074 @default.
- W327562175 hasConcept C104317684 @default.
- W327562175 hasConcept C126322002 @default.
- W327562175 hasConcept C143998085 @default.
- W327562175 hasConcept C185592680 @default.
- W327562175 hasConcept C2776256026 @default.
- W327562175 hasConcept C38180746 @default.
- W327562175 hasConcept C55493867 @default.
- W327562175 hasConcept C63363279 @default.
- W327562175 hasConcept C6856738 @default.
- W327562175 hasConcept C71924100 @default.
- W327562175 hasConceptScore W327562175C104317684 @default.
- W327562175 hasConceptScore W327562175C126322002 @default.
- W327562175 hasConceptScore W327562175C143998085 @default.
- W327562175 hasConceptScore W327562175C185592680 @default.
- W327562175 hasConceptScore W327562175C2776256026 @default.
- W327562175 hasConceptScore W327562175C38180746 @default.
- W327562175 hasConceptScore W327562175C55493867 @default.
- W327562175 hasConceptScore W327562175C63363279 @default.
- W327562175 hasConceptScore W327562175C6856738 @default.
- W327562175 hasConceptScore W327562175C71924100 @default.
- W327562175 hasIssue "11" @default.
- W327562175 hasLocation W3275621751 @default.
- W327562175 hasLocation W3275621752 @default.
- W327562175 hasOpenAccess W327562175 @default.
- W327562175 hasPrimaryLocation W3275621751 @default.
- W327562175 hasRelatedWork W1515918626 @default.
- W327562175 hasRelatedWork W2348529436 @default.
- W327562175 hasRelatedWork W2353723898 @default.
- W327562175 hasRelatedWork W2356783340 @default.
- W327562175 hasRelatedWork W2358195922 @default.
- W327562175 hasRelatedWork W2386874988 @default.
- W327562175 hasRelatedWork W2419775784 @default.
- W327562175 hasRelatedWork W3159490203 @default.
- W327562175 hasRelatedWork W4293436059 @default.
- W327562175 hasRelatedWork W848556315 @default.
- W327562175 hasVolume "36" @default.
- W327562175 isParatext "false" @default.
- W327562175 isRetracted "false" @default.
- W327562175 magId "327562175" @default.
- W327562175 workType "article" @default.