Matches in SemOpenAlex for { <https://semopenalex.org/work/W327665178> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W327665178 endingPage "370" @default.
- W327665178 startingPage "365" @default.
- W327665178 abstract "To gain knowledge about the behaviour of calpastatin (the specific inhibitor of the Ca(2+)-dependent thiol protease calpain) in the intact cell, we analysed the inhibitor by specific antibodies and determined its activity in erythrocytes from individuals 20-34 years old (young) and 70-93 years old (old). Differences between old and young in the behaviour of erythrocyte calpastatin were observed. Erythrocytes of old individuals had lower amounts of calpastatin and less calpastatin activity than those of young ones. A difference between old and young was also found in the molecular-mass distribution of calpastatin subunits. Increasing the erythrocyte Ca2+ induced changes in calpastatin in young individuals, rendering it similar to calpastatin in cells of old individuals. When calpastatin (isolated from erythrocytes of a young individual) was added to erythrocyte membranes, the initial binding and subsequent association of calpastatin with the membrane were lower in old than in young individuals. We had previously found that calpain binding and activation were enhanced in erythrocyte membranes from old individuals, along with enhanced degradation of band 3 (a major erythrocyte transmembrane anion-transport protein). The overall results indicate an interaction of calpain with calpastatin in the intact cell. Enhanced activation of erythrocyte calpain and degradation of calpastatin occur under conditions of increased cellular Ca2+ and in cells of the aged." @default.
- W327665178 created "2016-06-24" @default.
- W327665178 creator A5034875396 @default.
- W327665178 creator A5063323077 @default.
- W327665178 creator A5080850468 @default.
- W327665178 creator A5084066312 @default.
- W327665178 date "1994-12-01" @default.
- W327665178 modified "2023-09-23" @default.
- W327665178 title "Calpastatin in erythrocytes of young and old individuals" @default.
- W327665178 cites W1208244564 @default.
- W327665178 cites W1541285989 @default.
- W327665178 cites W1595696789 @default.
- W327665178 cites W1775749144 @default.
- W327665178 cites W1937918917 @default.
- W327665178 cites W1964270286 @default.
- W327665178 cites W1966645588 @default.
- W327665178 cites W1971883253 @default.
- W327665178 cites W1972234658 @default.
- W327665178 cites W1977969332 @default.
- W327665178 cites W1983003973 @default.
- W327665178 cites W1988916131 @default.
- W327665178 cites W2003820953 @default.
- W327665178 cites W2004355923 @default.
- W327665178 cites W2006199126 @default.
- W327665178 cites W2018289835 @default.
- W327665178 cites W2036532215 @default.
- W327665178 cites W2040086038 @default.
- W327665178 cites W2051909445 @default.
- W327665178 cites W2056001005 @default.
- W327665178 cites W2067199913 @default.
- W327665178 cites W2075105264 @default.
- W327665178 cites W2090600204 @default.
- W327665178 cites W2093076184 @default.
- W327665178 cites W2100837269 @default.
- W327665178 cites W2101108802 @default.
- W327665178 cites W2267906346 @default.
- W327665178 cites W2409428132 @default.
- W327665178 cites W2417988496 @default.
- W327665178 cites W4290246437 @default.
- W327665178 doi "https://doi.org/10.1042/bj3040365" @default.
- W327665178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1137502" @default.
- W327665178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7998969" @default.
- W327665178 hasPublicationYear "1994" @default.
- W327665178 type Work @default.
- W327665178 sameAs 327665178 @default.
- W327665178 citedByCount "23" @default.
- W327665178 countsByYear W3276651782012 @default.
- W327665178 countsByYear W3276651782013 @default.
- W327665178 countsByYear W3276651782014 @default.
- W327665178 countsByYear W3276651782015 @default.
- W327665178 countsByYear W3276651782017 @default.
- W327665178 crossrefType "journal-article" @default.
- W327665178 hasAuthorship W327665178A5034875396 @default.
- W327665178 hasAuthorship W327665178A5063323077 @default.
- W327665178 hasAuthorship W327665178A5080850468 @default.
- W327665178 hasAuthorship W327665178A5084066312 @default.
- W327665178 hasBestOaLocation W3276651782 @default.
- W327665178 hasConcept C153911025 @default.
- W327665178 hasConcept C181199279 @default.
- W327665178 hasConcept C185592680 @default.
- W327665178 hasConcept C2776557347 @default.
- W327665178 hasConcept C2777488010 @default.
- W327665178 hasConcept C55493867 @default.
- W327665178 hasConcept C56928146 @default.
- W327665178 hasConcept C86803240 @default.
- W327665178 hasConcept C95444343 @default.
- W327665178 hasConceptScore W327665178C153911025 @default.
- W327665178 hasConceptScore W327665178C181199279 @default.
- W327665178 hasConceptScore W327665178C185592680 @default.
- W327665178 hasConceptScore W327665178C2776557347 @default.
- W327665178 hasConceptScore W327665178C2777488010 @default.
- W327665178 hasConceptScore W327665178C55493867 @default.
- W327665178 hasConceptScore W327665178C56928146 @default.
- W327665178 hasConceptScore W327665178C86803240 @default.
- W327665178 hasConceptScore W327665178C95444343 @default.
- W327665178 hasIssue "2" @default.
- W327665178 hasLocation W3276651781 @default.
- W327665178 hasLocation W3276651782 @default.
- W327665178 hasLocation W3276651783 @default.
- W327665178 hasLocation W3276651784 @default.
- W327665178 hasOpenAccess W327665178 @default.
- W327665178 hasPrimaryLocation W3276651781 @default.
- W327665178 hasRelatedWork W1964218316 @default.
- W327665178 hasRelatedWork W2004355923 @default.
- W327665178 hasRelatedWork W200684778 @default.
- W327665178 hasRelatedWork W2017082371 @default.
- W327665178 hasRelatedWork W2023339576 @default.
- W327665178 hasRelatedWork W2043941577 @default.
- W327665178 hasRelatedWork W2073563753 @default.
- W327665178 hasRelatedWork W2078306521 @default.
- W327665178 hasRelatedWork W2359549956 @default.
- W327665178 hasRelatedWork W327665178 @default.
- W327665178 hasVolume "304" @default.
- W327665178 isParatext "false" @default.
- W327665178 isRetracted "false" @default.
- W327665178 magId "327665178" @default.
- W327665178 workType "article" @default.