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• W328213066 abstract "During embryonic development, the somatic gonad precursors become populated by the primordial germ cells. While many genes have been identified, the highly regulated process of germ cell migration across the primordial midgut epithelium is not well characterized. Here, we describe three spot (tspt), a gene which interacts with tre1 during cross-epithelial migration. The tspt mutant was created in an EMS mutagenesis screen performed previously (COFFMAN et al. 2002). Embryos from tspt mothers (referred to as tspt embryos in this paper) appear to exhibit restricted germ cell migration through the posterior midgut, resulting in a population of germ cells that remain associated with the endoderm through stage 16. We show that tspt is a maternally required migration gene, as well as a temperature sensitive mutant. The three spot mutation maps to the region distal to the 9B polytene band and proximal to the 15F polytene band. We have identified two deletion regions that fail to complement tspt. One of the regions maps to the same region defined by recombination mapping. P-element insertions for 19 genes in and around this region were tested for germ cell phenotypes. Surprisingly, three of the nineteen exhibited germ cell defects. The tre1 G-protein coupled receptor gene has been shown to be necessary for both programmed cell death and the migration of germ cells across the midgut (COFFMAN et al. 2002; KUNWAR et al. 2003). The scattershot allele of tre1 (COFFMAN et al. 2002) fails to complement tspt mutants, suggesting that they may be involved in the same or converging pathways during germ cell migration. Here we will describe the characterization of tspt mutants and the mapping of the tspt gene." @default.
• W328213066 created "2016-06-24" @default.
• W328213066 creator A5012080358 @default.
• W328213066 date "2018-08-13" @default.
• W328213066 modified "2023-10-16" @default.
• W328213066 title "Characterization of three spot, a mutation that disrupts germ cell migration of Drosophila melanogaster" @default.
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• W328213066 doi "https://doi.org/10.31274/rtd-180813-16699" @default.
• W328213066 hasPublicationYear "2018" @default.
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