Matches in SemOpenAlex for { <https://semopenalex.org/work/W328234281> ?p ?o ?g. }
- W328234281 endingPage "465" @default.
- W328234281 startingPage "453" @default.
- W328234281 abstract "Parkinson's disease (PD) can result in cognitive impairment. Executive dysfunction often appears early, followed by more widespread deficits later in the course of the disease. Disruption of parallel basal ganglia thalamo-cortical loops that subserve motor and cognitive function has been described in PD. However, there is emerging evidence that the default mode network, a cortical network that is active at rest with reduced activation during task performance, may also play a role in disease related cognitive decline.To determine the relative contribution of the executive control and default mode networks to parkinsonian executive dysfunction in medicated non-demented patients.We used BOLD fMRI to measure resting state functional connectivity in the executive control and default mode (DM) networks, and examined switching, processing speed, working memory/attention and motor performance in 14 medicated non-demented PD participants and 20 controls.Performance on neuropsychological measures was similar across groups. Functional connectivity was not different across disease conditions in the executive control network. DMN functional connectivity was decreased in the PD group, specifically between posterior cingulate, medial prefrontal, and inferior parietal nodes. Greater DMN functional connectivity was associated with faster processing speed in the PD group.The continuous relationship between DMN disconnection and executive task performance indicates a possible biological contributor to parkinsonian cognitive deficits. The dynamics of executive control network change may be different than that of the DMN, suggesting less sensitivity to early cognitive deficits." @default.
- W328234281 created "2016-06-24" @default.
- W328234281 creator A5021541475 @default.
- W328234281 creator A5031971991 @default.
- W328234281 creator A5041611929 @default.
- W328234281 creator A5042120960 @default.
- W328234281 creator A5044253009 @default.
- W328234281 creator A5048287731 @default.
- W328234281 creator A5052339193 @default.
- W328234281 creator A5054637868 @default.
- W328234281 date "2014-01-01" @default.
- W328234281 modified "2023-10-02" @default.
- W328234281 title "Resting State Functional Connectivity is Associated with Cognitive Dysfunction in Non-Demented People with Parkinson's Disease" @default.
- W328234281 cites W123122936 @default.
- W328234281 cites W1490631519 @default.
- W328234281 cites W1597262397 @default.
- W328234281 cites W1847168837 @default.
- W328234281 cites W1963924677 @default.
- W328234281 cites W1965325756 @default.
- W328234281 cites W1966684691 @default.
- W328234281 cites W1967642097 @default.
- W328234281 cites W1971309447 @default.
- W328234281 cites W1971498617 @default.
- W328234281 cites W1975008523 @default.
- W328234281 cites W1976792198 @default.
- W328234281 cites W1976923181 @default.
- W328234281 cites W1977761644 @default.
- W328234281 cites W1980742191 @default.
- W328234281 cites W1989722013 @default.
- W328234281 cites W1992161861 @default.
- W328234281 cites W1992373062 @default.
- W328234281 cites W1993541461 @default.
- W328234281 cites W1997301424 @default.
- W328234281 cites W2003244414 @default.
- W328234281 cites W2009021103 @default.
- W328234281 cites W2009494091 @default.
- W328234281 cites W2009576287 @default.
- W328234281 cites W2010478807 @default.
- W328234281 cites W2014370020 @default.
- W328234281 cites W2025917155 @default.
- W328234281 cites W2026582734 @default.
- W328234281 cites W2027346623 @default.
- W328234281 cites W2038012828 @default.
- W328234281 cites W2042933433 @default.
- W328234281 cites W2043037767 @default.
- W328234281 cites W2047657909 @default.
- W328234281 cites W2048645182 @default.
- W328234281 cites W2052289879 @default.
- W328234281 cites W2055345898 @default.
- W328234281 cites W2056765716 @default.
- W328234281 cites W2064996887 @default.
- W328234281 cites W2065226845 @default.
- W328234281 cites W2067490391 @default.
- W328234281 cites W2072011989 @default.
- W328234281 cites W2074145542 @default.
- W328234281 cites W2075278002 @default.
- W328234281 cites W2075714285 @default.
- W328234281 cites W2076472237 @default.
- W328234281 cites W2093307631 @default.
- W328234281 cites W2095422075 @default.
- W328234281 cites W2095438393 @default.
- W328234281 cites W2095642798 @default.
- W328234281 cites W2099652807 @default.
- W328234281 cites W2112519660 @default.
- W328234281 cites W2116658855 @default.
- W328234281 cites W2117381358 @default.
- W328234281 cites W2129930030 @default.
- W328234281 cites W2131881760 @default.
- W328234281 cites W2135475851 @default.
- W328234281 cites W2136435696 @default.
- W328234281 cites W2143285014 @default.
- W328234281 cites W2147295197 @default.
- W328234281 cites W2149885167 @default.
- W328234281 cites W2151128435 @default.
- W328234281 cites W2151369959 @default.
- W328234281 cites W2151384687 @default.
- W328234281 cites W2157875844 @default.
- W328234281 cites W2158592797 @default.
- W328234281 cites W2162010696 @default.
- W328234281 cites W2167720733 @default.
- W328234281 cites W2408759768 @default.
- W328234281 cites W2591706791 @default.
- W328234281 doi "https://doi.org/10.3233/jpd-130341" @default.
- W328234281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24662193" @default.
- W328234281 hasPublicationYear "2014" @default.
- W328234281 type Work @default.
- W328234281 sameAs 328234281 @default.
- W328234281 citedByCount "50" @default.
- W328234281 countsByYear W3282342812015 @default.
- W328234281 countsByYear W3282342812016 @default.
- W328234281 countsByYear W3282342812017 @default.
- W328234281 countsByYear W3282342812018 @default.
- W328234281 countsByYear W3282342812019 @default.
- W328234281 countsByYear W3282342812020 @default.
- W328234281 countsByYear W3282342812021 @default.
- W328234281 countsByYear W3282342812022 @default.
- W328234281 countsByYear W3282342812023 @default.
- W328234281 crossrefType "journal-article" @default.