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- W328301166 abstract "The effects of pyridine (PY), thiazole (TH) and pyrazine (PZ) on the expression of renal P450IIE1, IA1 and IA2 in rat have been examined by immunoblot analyses and enzymatic activity assays. The molecular basis of induction was characterized by slot blot hybridization analyses. PY produced a slight increase in renal IIE1. Hybridization analyses revealed that PY treatment over the 3d period resulted in a {approximately}50% decrease in IIE1 mRNA on day one followed by an {approximately}2-fold increase in IIE1 mRNA on day two and three. PY also produced a marginal increase in IA1 mRNA and 4-fold increase in IA2 mRNA. In contrast, the level of IIE1 in renal microsomes was elevated {approximately}3- to 4-fold following the administration of TH and PZ, as evidenced by immunoblot analyses and by p-nitro-phenol hydroxylase activity. Hybridization analyses revealed an {approximately}2- to 4-fold increase in IIE1, IA1 and IA2 mRNA levels by {approximately}3- to 4-fold and IA2 mRNA level by about 20-fold. These results suggest that PY, TH and PZ induce IIE1, IA1, and IA2 in rat kidney and that regulatory mechanism(s) governing induction of these proteins differ." @default.
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- W328301166 date "1991-03-15" @default.
- W328301166 modified "2023-09-24" @default.
- W328301166 title "Induction of renal cytochrome P450IIE1, IA1, and IA2 by aromatic nitrogen- and sulfur-containing heterocycles" @default.
- W328301166 hasPublicationYear "1991" @default.
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