Matches in SemOpenAlex for { <https://semopenalex.org/work/W328515560> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W328515560 endingPage "e0101019" @default.
- W328515560 startingPage "e0101019" @default.
- W328515560 abstract "Epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors are useful in treating different advanced human cancers; however, their clinical efficacy varies. This study detected K-ras mutations to predict the efficacy of EGFR-TK inhibitor cetuximab treatment on Chinese patients with metastatic colorectal cancer (mCRC). A total of 87 patients with metastatic colorectal cancer were treated with cetuximab for 2-16 months, in combination with chemotherapy between August 2008 and July 2012, and tissue samples were used to detect K-ras mutations. The data showed that K-ras mutation occurred in 27/87 (31%). The objective response rates and disease control rate in K-ras wild type and mutant patients were 42% (25/60) versus 11% (3/27) (p<0.05) and 60% (36/60) versus 26% (7/27) (p<0.05), respectively. Patients with the wild-type K-ras had significantly higher median survival times and progression-free survival, than patients with mutated K-ras (21 months versus 17 months, p=0.017; 10 months versus 6 months, p=0.6). These findings suggest that a high frequency of K-ras mutations occurs in Chinese mCRC patients and that K-ras mutation is required to select patients for eligibility for cetuximab therapy. Further prospective studies using a large sample size are needed to confirm these preliminary findings." @default.
- W328515560 created "2016-06-24" @default.
- W328515560 creator A5030267366 @default.
- W328515560 creator A5030929816 @default.
- W328515560 creator A5031297404 @default.
- W328515560 creator A5057704753 @default.
- W328515560 creator A5066222509 @default.
- W328515560 creator A5080092242 @default.
- W328515560 date "2015-05-07" @default.
- W328515560 modified "2023-10-06" @default.
- W328515560 title "Detection of K-ras Mutations in Predicting Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) Inhibitor in Patients with Metastatic Colorectal Cancer" @default.
- W328515560 cites W1965905026 @default.
- W328515560 cites W1983104536 @default.
- W328515560 cites W199842401 @default.
- W328515560 cites W2003246614 @default.
- W328515560 cites W2038124430 @default.
- W328515560 cites W2058273943 @default.
- W328515560 cites W2067337678 @default.
- W328515560 cites W2068595510 @default.
- W328515560 cites W2074473619 @default.
- W328515560 cites W2088293068 @default.
- W328515560 cites W2088710403 @default.
- W328515560 cites W2095201384 @default.
- W328515560 cites W2099461073 @default.
- W328515560 cites W2120490763 @default.
- W328515560 cites W2139248078 @default.
- W328515560 cites W2157416388 @default.
- W328515560 cites W2159594827 @default.
- W328515560 cites W2171111432 @default.
- W328515560 cites W2171399434 @default.
- W328515560 cites W2409888087 @default.
- W328515560 cites W2602544133 @default.
- W328515560 cites W4232777855 @default.
- W328515560 doi "https://doi.org/10.1371/journal.pone.0101019" @default.
- W328515560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4423938" @default.
- W328515560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25950441" @default.
- W328515560 hasPublicationYear "2015" @default.
- W328515560 type Work @default.
- W328515560 sameAs 328515560 @default.
- W328515560 citedByCount "4" @default.
- W328515560 countsByYear W3285155602017 @default.
- W328515560 countsByYear W3285155602021 @default.
- W328515560 countsByYear W3285155602022 @default.
- W328515560 crossrefType "journal-article" @default.
- W328515560 hasAuthorship W328515560A5030267366 @default.
- W328515560 hasAuthorship W328515560A5030929816 @default.
- W328515560 hasAuthorship W328515560A5031297404 @default.
- W328515560 hasAuthorship W328515560A5057704753 @default.
- W328515560 hasAuthorship W328515560A5066222509 @default.
- W328515560 hasAuthorship W328515560A5080092242 @default.
- W328515560 hasBestOaLocation W3285155601 @default.
- W328515560 hasConcept C121608353 @default.
- W328515560 hasConcept C126322002 @default.
- W328515560 hasConcept C143998085 @default.
- W328515560 hasConcept C26375932 @default.
- W328515560 hasConcept C2776694085 @default.
- W328515560 hasConcept C2778820342 @default.
- W328515560 hasConcept C2779438470 @default.
- W328515560 hasConcept C2779998722 @default.
- W328515560 hasConcept C502942594 @default.
- W328515560 hasConcept C526805850 @default.
- W328515560 hasConcept C71924100 @default.
- W328515560 hasConceptScore W328515560C121608353 @default.
- W328515560 hasConceptScore W328515560C126322002 @default.
- W328515560 hasConceptScore W328515560C143998085 @default.
- W328515560 hasConceptScore W328515560C26375932 @default.
- W328515560 hasConceptScore W328515560C2776694085 @default.
- W328515560 hasConceptScore W328515560C2778820342 @default.
- W328515560 hasConceptScore W328515560C2779438470 @default.
- W328515560 hasConceptScore W328515560C2779998722 @default.
- W328515560 hasConceptScore W328515560C502942594 @default.
- W328515560 hasConceptScore W328515560C526805850 @default.
- W328515560 hasConceptScore W328515560C71924100 @default.
- W328515560 hasIssue "5" @default.
- W328515560 hasLocation W3285155601 @default.
- W328515560 hasLocation W3285155602 @default.
- W328515560 hasLocation W3285155603 @default.
- W328515560 hasLocation W3285155604 @default.
- W328515560 hasLocation W3285155605 @default.
- W328515560 hasOpenAccess W328515560 @default.
- W328515560 hasPrimaryLocation W3285155601 @default.
- W328515560 hasRelatedWork W1968282664 @default.
- W328515560 hasRelatedWork W2039295880 @default.
- W328515560 hasRelatedWork W2045259217 @default.
- W328515560 hasRelatedWork W2094962167 @default.
- W328515560 hasRelatedWork W2147881050 @default.
- W328515560 hasRelatedWork W2317555516 @default.
- W328515560 hasRelatedWork W2779013171 @default.
- W328515560 hasRelatedWork W2943513312 @default.
- W328515560 hasRelatedWork W3168072189 @default.
- W328515560 hasRelatedWork W4225893764 @default.
- W328515560 hasVolume "10" @default.
- W328515560 isParatext "false" @default.
- W328515560 isRetracted "false" @default.
- W328515560 magId "328515560" @default.
- W328515560 workType "article" @default.