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- W329377781 abstract "This chapter focuses on the release mechanism of transmitters. It has been demonstrated that Ach is released upon stimulation of skeletal motor nerves and upon activation of preganglionic sympathetic fibers. The same mechanisms in the central nervous system (CNS), not unequivocally, were also proposed. In one study, while recording from the immediate region of synapse in the skeletal muscle of vertebrates, the random appearance of minute flactuations in the resting potential was observed, the direction of which was always depolarization. Later, it was showed, however, that the direction of the minute fluctuation of potentials in the stretch receptor neuron of crayfish was always hyperpolarization. This is conceivable because it has been well documented that the neuron is exclusively innervated by the inhibitory inputs. Subsequent studies have shown that these small depolarizations are produced not by a molecular overspill but by the random release of quantized packets of transmitter. It was proved that the release is not because of local excitation of terminal axon branches and hence, local excitation should be able to produce a synchronized depolarization in a wider area of nerve terminal." @default.
- W329377781 created "2016-06-24" @default.
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- W329377781 date "1975-01-01" @default.
- W329377781 modified "2023-10-16" @default.
- W329377781 title "The Release Mechanism of Transmitters" @default.
- W329377781 doi "https://doi.org/10.1016/b978-0-444-99872-9.50010-1" @default.
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