FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W32971372> ?p ?o ?g. }

• W32971372 abstract "Munkank soran az extracellularis vezikulak izolalasanak es detektalasanak szamos meghatarozo preanalitikai es analitikai parameterere hivtuk fel a figyelmet. Elsőkent mutattunk ra, hogy a mikrovezikulak es a feherje-aggregatumok biofizikai parameterei jelentős mertekben atfednek, es ez zavarhatja a mikrovezikulak mereset. Kidolgoztuk annak modszeret, hogy egyazon biologiai forrasbol szarmazo kulonboző vezikula populaciokat parhuzamosan, nagy mennyisegben, intakt formaban tudjunk izolalni. Osszehasonlito proteomikai elemzest vegeztunk thymus eredetű apoptotikus testek es mikrovezikulak eseteben. Szamos T sejt jelatvitelben es immunfolyamatokban szerepet jatszo feherjet es autoantigent azonositottunk. Igazoltuk, hogy T sejt eredetű citokinek es extracellularis vezikulak egyuttes hatasat monocitak genexpressziojara. Igazoltuk, hogy a mikrovezikulak onallo ionhaztartassal rendelkeznek. Kimutattuk, hogy thymocyta exoszomak nem tartalmaznak riboszomalis RNS-eket, azonban feldusulnak bennuk kis RNS-ek (pl. bizonyos miRNS-ek). Polymyositises betegekben emelkedett keringő mikrovezikula szamot mutattunk ki, mely korrelalt a betegseg bizonyos klinikai parametereivel. Vegul elsőkent igazoltuk, hogy egeszseges T sejt eredetű mikrovezikulak CD62P-CD161 kolcsonhatas reven specifikusan kotődnek monocitak felszinehez. | In our work we drove attention to several pre-analytical and analytical parameters affecting isolation and detection of work extracellular vesicles. We were the first to describe that microvesicles share biophysical parameters with protein aggregates which may confound microvesicle assessment by flow cytometry. We developed protocols for the isolation of large amounts of intact vesicle types secreted simultaneously by the same biological source. We carried comparative proteomic analysis of murine thymus derived apoptotic bodies and microvesicles. We identified large number of proteins involved in T cell signaling or immune functions as well as autoantigens within these structures. We provided evidence fro crosstalk between T cell derived extracellular vesicles and cytokines on the gene expression of monocytes. We have shown that microvesicles possess autonomous ion homeostasis. We found that thymocyte derived exosomes lacked the 18S and 28S ribosomal RNA molecules, while they were enriched in small RNA species (e.g. certain miRNAs). We described that patients with polyomyelitis were characterized by elevated levels of circulating microvesicle. Monocyte- and B cell-derived microvesicle numbers correlated with certain clinical parameters of the diseases. Finally, for the first time we showed that HLA-G+, trophoblast-derived microvesicles isolated from healthy pregnant blood plasma samples, bound specifically to T cells via CD62P-CD161 interaction, and induced STAT3 phosphorylation." @default.
• W32971372 created "2016-06-24" @default.
• W32971372 creator A5008517340 @default.
• W32971372 creator A5016498354 @default.
• W32971372 creator A5027183622 @default.
• W32971372 creator A5028662130 @default.
• W32971372 creator A5034813816 @default.
• W32971372 creator A5047340397 @default.
• W32971372 creator A5053441867 @default.
• W32971372 creator A5059383496 @default.
• W32971372 creator A5068836281 @default.
• W32971372 creator A5083366475 @default.
• W32971372 creator A5086107375 @default.
• W32971372 creator A5086262207 @default.
• W32971372 creator A5088899125 @default.
• W32971372 date "2012-01-01" @default.
• W32971372 modified "2023-10-16" @default.
• W32971372 title "A sejtek közti kommunikáció újonnan azonosított mikrovezikulum-útjának vizsgálata = Analysis of cell-derived microvesicles that represent novel players in intercellular communication" @default.
• W32971372 hasPublicationYear "2012" @default.
• W32971372 type Work @default.
• W32971372 sameAs 32971372 @default.
• W32971372 citedByCount "0" @default.
• W32971372 crossrefType "journal-article" @default.
• W32971372 hasAuthorship W32971372A5008517340 @default.
• W32971372 hasAuthorship W32971372A5016498354 @default.
• W32971372 hasAuthorship W32971372A5027183622 @default.
• W32971372 hasAuthorship W32971372A5028662130 @default.
• W32971372 hasAuthorship W32971372A5034813816 @default.
• W32971372 hasAuthorship W32971372A5047340397 @default.
• W32971372 hasAuthorship W32971372A5053441867 @default.
• W32971372 hasAuthorship W32971372A5059383496 @default.
• W32971372 hasAuthorship W32971372A5068836281 @default.
• W32971372 hasAuthorship W32971372A5083366475 @default.
• W32971372 hasAuthorship W32971372A5086107375 @default.
• W32971372 hasAuthorship W32971372A5086262207 @default.
• W32971372 hasAuthorship W32971372A5088899125 @default.
• W32971372 hasConcept C104317684 @default.
• W32971372 hasConcept C145059251 @default.
• W32971372 hasConcept C153911025 @default.
• W32971372 hasConcept C20518536 @default.
• W32971372 hasConcept C2909763251 @default.
• W32971372 hasConcept C2992929900 @default.
• W32971372 hasConcept C553184892 @default.
• W32971372 hasConcept C55493867 @default.
• W32971372 hasConcept C86803240 @default.
• W32971372 hasConcept C95444343 @default.
• W32971372 hasConceptScore W32971372C104317684 @default.
• W32971372 hasConceptScore W32971372C145059251 @default.
• W32971372 hasConceptScore W32971372C153911025 @default.
• W32971372 hasConceptScore W32971372C20518536 @default.
• W32971372 hasConceptScore W32971372C2909763251 @default.
• W32971372 hasConceptScore W32971372C2992929900 @default.
• W32971372 hasConceptScore W32971372C553184892 @default.
• W32971372 hasConceptScore W32971372C55493867 @default.
• W32971372 hasConceptScore W32971372C86803240 @default.
• W32971372 hasConceptScore W32971372C95444343 @default.
• W32971372 hasLocation W329713721 @default.
• W32971372 hasOpenAccess W32971372 @default.
• W32971372 hasPrimaryLocation W329713721 @default.
• W32971372 hasRelatedWork W1000098286 @default.
• W32971372 hasRelatedWork W1044691158 @default.
• W32971372 hasRelatedWork W117627159 @default.
• W32971372 hasRelatedWork W122002400 @default.
• W32971372 hasRelatedWork W123074350 @default.
• W32971372 hasRelatedWork W140525078 @default.
• W32971372 hasRelatedWork W142667690 @default.
• W32971372 hasRelatedWork W16713901 @default.
• W32971372 hasRelatedWork W2272643401 @default.
• W32971372 hasRelatedWork W366295410 @default.
• W32971372 hasRelatedWork W418836812 @default.
• W32971372 hasRelatedWork W576386871 @default.
• W32971372 hasRelatedWork W606540316 @default.
• W32971372 hasRelatedWork W84567734 @default.
• W32971372 hasRelatedWork W84977728 @default.
• W32971372 hasRelatedWork W881148 @default.
• W32971372 hasRelatedWork W981496541 @default.
• W32971372 hasRelatedWork W984950279 @default.
• W32971372 hasRelatedWork W1769444937 @default.
• W32971372 hasRelatedWork W994214728 @default.
• W32971372 isParatext "false" @default.
• W32971372 isRetracted "false" @default.
• W32971372 magId "32971372" @default.
• W32971372 workType "article" @default.