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- W330236468 abstract "Publisher Summary This chapter focuses on the morphologic aspects of insulin secretion and binding to specific cell-surface receptors. The morphologic and/or autoradiographic and biochemical aspects in the B-cell of the islet of Langerhans involves the following steps: (1) budding of membrane-limited microvesicles from transitional elements of the rough endoplasmic reticulum (RER) containing polypeptide material; (2) migration of the microvesicles toward the convex face of the Golgi complex, where microvesicles appear to fuse together and form the outermost Golgi cisternae; (3) concentration of the polypeptide material in the form of membrane-limited secretory granules at the concave face of the Golgi apparatus; and (4) release of the secretory material at the cell surface. The translocation of newly synthetized polypeptides from the budding transitional elements of the RER to the Golgi cisternae has been shown in several secretory cell types—such as pancreatic acinar cell, B-cell of the islet of Langerhans, and in the chief cell of the parathyroid gland—to be energy-dependent. This means that the transfer could be blocked for the treatment of the cells with inhibitors of respiration and/or of oxidative phosphorylation." @default.
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- W330236468 date "1978-01-01" @default.
- W330236468 modified "2023-10-17" @default.
- W330236468 title "Less-Understood Aspects of the Morphology of Insulin Secretion and Binding" @default.
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- W330236468 doi "https://doi.org/10.1016/b978-0-12-571134-0.50007-7" @default.
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