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• W33025869 abstract "Cell death occurs in all tissues of the mammalian body, most prominently in three areas: the digestive tract, the skin, and the hematopoietic system, of which the immune system is part. Each of these is an interface between the body and the external world. As such, they are exposed to a variety of physical, chemical, and biological threats. It might be possible to toughen these contact surfaces in an attempt to make them impervious to injury, as is the case in many invertebrates, which possess nearly impenetrable exoskeletons. The inconveniences of this design are apparent, however, when an invertebrate tries to grow. It must soften and shed its exoskeleton, leaving it susceptible to predators. A better solution is to replace cells in the contact zones regularly and frequently, as is the case in man. This offers an additional advantage: if a cell sustains an injury that results in DNA damage, chances are that the cell will die before the mutation is locked in by cell division. If it were not for this mechanism, it is possible that skin and gastrointestinal tumors would be far more frequent than they are. Similarly, cells of the innate and acquired immune responses have, in general, short life expectancies; one of them, the polymorphonuclear neutrophil, has probably the shortest lifespan in the human body—usually less than a day. Most lymphocytes—the cells that carry out the work of acquired immunity—are also short-lived, and furthermore, owing to extraordinary demands that are made on their specificity and reactivity, risk death at many stages in their lives. We review the most interesting examples of programmed (and, to a lesser extent, unprogrammed) cell death in the immune system. We begin with an overview of immunity, so that apoptotic events may be placed in context." @default.
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• W33025869 date "2003-01-01" @default.
• W33025869 modified "2023-09-23" @default.
• W33025869 title "Cell Death in Immune, Inflammatory, and Stress Responses" @default.
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• W33025869 doi "https://doi.org/10.1007/978-1-59259-361-3_13" @default.
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