FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W330564303> ?p ?o ?g. }

• W330564303 endingPage "835" @default.
• W330564303 startingPage "830" @default.
• W330564303 abstract "Abstract We have studied membrane fluidity changes in polymorphonuclear leukocytes (PMN) during phagocytosis. Membrane fluidity was assessed by electron spin resonance (ESR) using a nitroxide-substituted stearic acid analog (5DS) as a spin probe. PMN from normal subjects and from 3 CGD patients (2 males, 1 female) were incubated in Kreb's Ringers phosphate with or without opsonized zymosan. ESR spectra were obtained and the order parameter (S), which is inversely related to membrane fluidity, was calculated. Without zymosan addition, S for normal (0.638) and for CGD (0.635) were not significantly different (p less than 0.35). The S values indicate that under resting conditions the molecular environment of the CGD membrane is similar to that of normal PMN membranes. However, with addition of opsonized zymosan, the normal, but not the CGD, PMN showed a significant increase (CGD, S = 0.638; normal, S = 0.647; p less than 0.001). This change in S for the normals is consistent with a more restricted movement of 5DS. Treatment of normal PMN with a mixture of scavengers specific for H2O2 (catalase, 1600 U/ml), O2-.(superoxide dismutase, 100 micrograms/ml), and for HO., (sodium benzoate, 1mM) during zymosan stimulation gave S values similar to those of resting cells. Catalase alone also lowered S value, suggesting that H2O2 was instrumental in causing the initial S value increase. This idea was supported by studies in which CGD cells were incubated with zymosan in the presence of glucose oxidase, an enzyme that catalyzes glucose oxidation resulting in the direct reduction of molecular oxygen to H2O2. Our results indicate that reduced O2 by- products, particularly H2O2, can cause altered biophysical properties of PMN membrane during phagocytosis." @default.
• W330564303 created "2016-06-24" @default.
• W330564303 creator A5020833020 @default.
• W330564303 creator A5031232083 @default.
• W330564303 creator A5032031578 @default.
• W330564303 creator A5073108248 @default.
• W330564303 date "1981-10-01" @default.
• W330564303 modified "2023-10-16" @default.
• W330564303 title "Membrane fluidity changes accompanying phagocytosis in normal and in chronic granulomatous disease polymorphonuclear leukocytes" @default.
• W330564303 cites W1530859280 @default.
• W330564303 cites W1900423039 @default.
• W330564303 cites W1964822433 @default.
• W330564303 cites W1969266136 @default.
• W330564303 cites W1985752187 @default.
• W330564303 cites W1987093267 @default.
• W330564303 cites W2000319039 @default.
• W330564303 cites W2009826969 @default.
• W330564303 cites W2023122744 @default.
• W330564303 cites W2029322088 @default.
• W330564303 cites W2038801459 @default.
• W330564303 cites W2039128689 @default.
• W330564303 cites W2040534938 @default.
• W330564303 cites W2045027601 @default.
• W330564303 cites W2092766784 @default.
• W330564303 cites W2098621632 @default.
• W330564303 cites W2113842973 @default.
• W330564303 cites W2114005636 @default.
• W330564303 cites W2165646729 @default.
• W330564303 cites W2282755628 @default.
• W330564303 cites W2333505646 @default.
• W330564303 cites W2474474013 @default.
• W330564303 cites W2499707344 @default.
• W330564303 cites W2502775542 @default.
• W330564303 cites W87350884 @default.
• W330564303 doi "https://doi.org/10.1182/blood.v58.4.830.830" @default.
• W330564303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7272511" @default.
• W330564303 hasPublicationYear "1981" @default.
• W330564303 type Work @default.
• W330564303 sameAs 330564303 @default.
• W330564303 citedByCount "33" @default.
• W330564303 countsByYear W3305643032022 @default.
• W330564303 countsByYear W3305643032023 @default.
• W330564303 crossrefType "journal-article" @default.
• W330564303 hasAuthorship W330564303A5020833020 @default.
• W330564303 hasAuthorship W330564303A5031232083 @default.
• W330564303 hasAuthorship W330564303A5032031578 @default.
• W330564303 hasAuthorship W330564303A5073108248 @default.
• W330564303 hasBestOaLocation W3305643031 @default.
• W330564303 hasConcept C122398194 @default.
• W330564303 hasConcept C126322002 @default.
• W330564303 hasConcept C134018914 @default.
• W330564303 hasConcept C160448771 @default.
• W330564303 hasConcept C181199279 @default.
• W330564303 hasConcept C185592680 @default.
• W330564303 hasConcept C202751555 @default.
• W330564303 hasConcept C203014093 @default.
• W330564303 hasConcept C24998067 @default.
• W330564303 hasConcept C2775838275 @default.
• W330564303 hasConcept C2777983669 @default.
• W330564303 hasConcept C2778870864 @default.
• W330564303 hasConcept C2778979269 @default.
• W330564303 hasConcept C2779719074 @default.
• W330564303 hasConcept C2780795997 @default.
• W330564303 hasConcept C41625074 @default.
• W330564303 hasConcept C55493867 @default.
• W330564303 hasConcept C71924100 @default.
• W330564303 hasConcept C86803240 @default.
• W330564303 hasConcept C89372155 @default.
• W330564303 hasConceptScore W330564303C122398194 @default.
• W330564303 hasConceptScore W330564303C126322002 @default.
• W330564303 hasConceptScore W330564303C134018914 @default.
• W330564303 hasConceptScore W330564303C160448771 @default.
• W330564303 hasConceptScore W330564303C181199279 @default.
• W330564303 hasConceptScore W330564303C185592680 @default.
• W330564303 hasConceptScore W330564303C202751555 @default.
• W330564303 hasConceptScore W330564303C203014093 @default.
• W330564303 hasConceptScore W330564303C24998067 @default.
• W330564303 hasConceptScore W330564303C2775838275 @default.
• W330564303 hasConceptScore W330564303C2777983669 @default.
• W330564303 hasConceptScore W330564303C2778870864 @default.
• W330564303 hasConceptScore W330564303C2778979269 @default.
• W330564303 hasConceptScore W330564303C2779719074 @default.
• W330564303 hasConceptScore W330564303C2780795997 @default.
• W330564303 hasConceptScore W330564303C41625074 @default.
• W330564303 hasConceptScore W330564303C55493867 @default.
• W330564303 hasConceptScore W330564303C71924100 @default.
• W330564303 hasConceptScore W330564303C86803240 @default.
• W330564303 hasConceptScore W330564303C89372155 @default.
• W330564303 hasIssue "4" @default.
• W330564303 hasLocation W3305643031 @default.
• W330564303 hasOpenAccess W330564303 @default.
• W330564303 hasPrimaryLocation W3305643031 @default.
• W330564303 hasRelatedWork W1482406849 @default.
• W330564303 hasRelatedWork W1977267245 @default.
• W330564303 hasRelatedWork W2018206247 @default.
• W330564303 hasRelatedWork W2028516203 @default.
• W330564303 hasRelatedWork W2128688376 @default.
• W330564303 hasRelatedWork W2148068424 @default.

• next