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- W330731027 abstract "The complement system, an important part of innate immunity, plays a critical role in pathogen clearance. Unregulated complement activation is likely to play a crucial role in the pathogenesis of acute lung injury (ALI) induced by highly pathogenic virus including influenza A viruses H5N1, H7N9, and severe acute respiratory syndrome (SARS) coronavirus. In highly pathogenic virus-induced acute lung diseases, high levels of chemotactic and anaphylatoxic C5a were produced as a result of excessive complement activaiton. Overproduced C5a displays powerful biological activities in activation of phagocytic cells, generation of oxidants, and inflammatory sequelae named cytokine storm, and so on. Blockade of C5a signaling have been implicated in the treatment of ALI induced by highly pathogenic virus. Herein, we review the literature that links C5a and ALI, and review our understanding of the mechanisms by which C5a affects ALI during highly pathogenic viral infection. In particular, we discuss the potential of the blockade of C5a signaling to treat ALI induced by highly pathogenic viruses." @default.
- W330731027 created "2016-06-24" @default.
- W330731027 creator A5027597262 @default.
- W330731027 creator A5042614311 @default.
- W330731027 creator A5060514130 @default.
- W330731027 creator A5063391535 @default.
- W330731027 creator A5067940286 @default.
- W330731027 date "2015-01-01" @default.
- W330731027 modified "2023-10-18" @default.
- W330731027 title "The role of C5a in acute lung injury induced by highly pathogenic viral infections" @default.
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