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- W330893014 abstract "In current anticancer therapies, most cytostatic agents impair cell division by crosslinking DNA (e.g. cis-platin or alkylating agents), disrupting the cytoskeleton (e.g. vinblastine) or rectifying the cytoskeleton (e.g. taxol). In a new approach to cancer chemotherapy, the cell membrane was described as a target for cytostatic agents. It is known that alkyl-lysophospholipids possess antineoplastic properties in vitro and in vivo1, leading to the development of an other class of antiproliferative phospholipid analogues, the alkylphosphocholines. One of these phospholipid analogues, hexadecylphosphocholine (HePC), has been shown to inhibit cell proliferation and tumour growth 2–4." @default.
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- W330893014 date "1996-01-01" @default.
- W330893014 modified "2023-09-23" @default.
- W330893014 title "Phosphatidylcholine Biosynthesis as a Target for Phospholipid Analogues" @default.
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- W330893014 doi "https://doi.org/10.1007/978-1-4899-0179-8_53" @default.
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