Matches in SemOpenAlex for { <https://semopenalex.org/work/W33099456> ?p ?o ?g. }
- W33099456 abstract "Central nervous system (CNS) tumour pathogenesis probably is a multi-step process in which tumour suppressor gene inactivation and oncogene activation and overexpression play a part, along with alterations in cell cycle progression, abnormalities in signal transduction pathways, glial cell invasion, and angiogenesis (Nagane et al. 1997; Ueki et al. 2002). The role of growth factors in this process has increasingly been studied over the last few years. This chapter summarizes the available data, usually derived from adult patients, and discusses their limitations as well as their potential influence on future therapeutic strategies. One of the most common types of brain tumours, malignant gliomas, may arise via a number of apparently distinct molecular pathways, illustrated in Table 11.1. For example, glioblastoma multiforme (GBM) can be divided into at least two distinct genetic subsets: those characterized by p53 mutations and allelic loss of chromosome 17p in the absence of epidermal growth factor receptor (EGFR) gene amplification, and those with EGFR gene amplification but no p53 mutations or chromosome 17p loss. Tumours with p53 mutations occur primarily in younger patients and those with EGFR gene amplification arise primarily in older patients (Louis 1996). Molecular classification of gliomas is a major challenge in the effort to improve therapeutic decisions." @default.
- W33099456 created "2016-06-24" @default.
- W33099456 creator A5024681233 @default.
- W33099456 creator A5044089012 @default.
- W33099456 creator A5055289994 @default.
- W33099456 date "2003-01-01" @default.
- W33099456 modified "2023-09-27" @default.
- W33099456 title "Growth Factor Expression in Central Nervous System Tumours" @default.
- W33099456 cites W1276188711 @default.
- W33099456 cites W1602223278 @default.
- W33099456 cites W1945007559 @default.
- W33099456 cites W1967089657 @default.
- W33099456 cites W1969328947 @default.
- W33099456 cites W1973033337 @default.
- W33099456 cites W1982904703 @default.
- W33099456 cites W1984284981 @default.
- W33099456 cites W1984847121 @default.
- W33099456 cites W1997664229 @default.
- W33099456 cites W2001598945 @default.
- W33099456 cites W2005768909 @default.
- W33099456 cites W2007680735 @default.
- W33099456 cites W2009946441 @default.
- W33099456 cites W2010278115 @default.
- W33099456 cites W2017301682 @default.
- W33099456 cites W2021105592 @default.
- W33099456 cites W2021317620 @default.
- W33099456 cites W2028516762 @default.
- W33099456 cites W2033480740 @default.
- W33099456 cites W2044351980 @default.
- W33099456 cites W2044930054 @default.
- W33099456 cites W2048758017 @default.
- W33099456 cites W2050720945 @default.
- W33099456 cites W2054062171 @default.
- W33099456 cites W2055268714 @default.
- W33099456 cites W2058006748 @default.
- W33099456 cites W2069094027 @default.
- W33099456 cites W2076479500 @default.
- W33099456 cites W2078274083 @default.
- W33099456 cites W2085484338 @default.
- W33099456 cites W2085820828 @default.
- W33099456 cites W2087089518 @default.
- W33099456 cites W2091736771 @default.
- W33099456 cites W2094249300 @default.
- W33099456 cites W2097302582 @default.
- W33099456 cites W2122011934 @default.
- W33099456 cites W2122961418 @default.
- W33099456 cites W2131901676 @default.
- W33099456 cites W2143739956 @default.
- W33099456 cites W2144021190 @default.
- W33099456 cites W2277239386 @default.
- W33099456 cites W2417808079 @default.
- W33099456 cites W33484130 @default.
- W33099456 cites W343355683 @default.
- W33099456 cites W4246790415 @default.
- W33099456 doi "https://doi.org/10.1007/978-3-642-55613-5_11" @default.
- W33099456 hasPublicationYear "2003" @default.
- W33099456 type Work @default.
- W33099456 sameAs 33099456 @default.
- W33099456 citedByCount "0" @default.
- W33099456 crossrefType "book-chapter" @default.
- W33099456 hasAuthorship W33099456A5024681233 @default.
- W33099456 hasAuthorship W33099456A5044089012 @default.
- W33099456 hasAuthorship W33099456A5055289994 @default.
- W33099456 hasConcept C104317684 @default.
- W33099456 hasConcept C121608353 @default.
- W33099456 hasConcept C169760540 @default.
- W33099456 hasConcept C180754005 @default.
- W33099456 hasConcept C2778227246 @default.
- W33099456 hasConcept C2778264664 @default.
- W33099456 hasConcept C2779438470 @default.
- W33099456 hasConcept C2781018059 @default.
- W33099456 hasConcept C29537977 @default.
- W33099456 hasConcept C501734568 @default.
- W33099456 hasConcept C502942594 @default.
- W33099456 hasConcept C529278444 @default.
- W33099456 hasConcept C54355233 @default.
- W33099456 hasConcept C555283112 @default.
- W33099456 hasConcept C62478195 @default.
- W33099456 hasConcept C7602840 @default.
- W33099456 hasConcept C86803240 @default.
- W33099456 hasConceptScore W33099456C104317684 @default.
- W33099456 hasConceptScore W33099456C121608353 @default.
- W33099456 hasConceptScore W33099456C169760540 @default.
- W33099456 hasConceptScore W33099456C180754005 @default.
- W33099456 hasConceptScore W33099456C2778227246 @default.
- W33099456 hasConceptScore W33099456C2778264664 @default.
- W33099456 hasConceptScore W33099456C2779438470 @default.
- W33099456 hasConceptScore W33099456C2781018059 @default.
- W33099456 hasConceptScore W33099456C29537977 @default.
- W33099456 hasConceptScore W33099456C501734568 @default.
- W33099456 hasConceptScore W33099456C502942594 @default.
- W33099456 hasConceptScore W33099456C529278444 @default.
- W33099456 hasConceptScore W33099456C54355233 @default.
- W33099456 hasConceptScore W33099456C555283112 @default.
- W33099456 hasConceptScore W33099456C62478195 @default.
- W33099456 hasConceptScore W33099456C7602840 @default.
- W33099456 hasConceptScore W33099456C86803240 @default.
- W33099456 hasLocation W330994561 @default.
- W33099456 hasOpenAccess W33099456 @default.
- W33099456 hasPrimaryLocation W330994561 @default.