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- W3311279 endingPage "186" @default.
- W3311279 startingPage "177" @default.
- W3311279 abstract "Genetic variability is the clay of evolution, providing the base material on which adaptation and speciation depend. It is often assumed that most interspecific differences in variability are due primarily to population size effects, with bottlenecked populations carrying less variability than those of stable size. However, we show that population bottlenecks are unlikely to be the only factor, even in classic case studies such as the northern elephant seal and the cheetah, where genetic polymorphism is virtually absent. Instead, we suggest that the low levels of variability observed in endangered populations are more likely to result from a combination of publication biases, which tend to inflate the level of variability which is considered 'normal', and inbreeding effects, which may hasten loss of variability due to drift. To account for species with large population sizes but low variability we advance three hypotheses. First, it is known that certain metapopulation structures can result in effective population sizes far below the census size. Second, there is increasing evidence that heterozygous sites mutate more frequently than equivalent homozygous sites, plausibly because mismatch repair between homologous chromosomes during meiosis provides extra opportunities to mutate. Such a mechanism would undermine the simple relationship between heterozygosity and effective population size. Third, the fact that related species that differ greatly in variability implies that large amounts of variability can be gained or lost rapidly. We argue that such cases are best explained by rapid loss through a genome-wide selective sweep, and suggest a mechanism by which this could come about, based on forced changes to a control gene inducing coevolution in the genes it controls. Our model, based on meiotic drive in mammals, but easily extended to other systems, would tend to facilitate population isolation by generating molecular incompatabilities. Circumstances can even be envisioned in which the process could provide intrinsic impetus to speciation." @default.
- W3311279 created "2016-06-24" @default.
- W3311279 creator A5037340076 @default.
- W3311279 creator A5057285365 @default.
- W3311279 date "1998-02-28" @default.
- W3311279 modified "2023-10-18" @default.
- W3311279 title "Factors affecting levels of genetic diversity in natural populations" @default.
- W3311279 cites W1566245339 @default.
- W3311279 cites W1581127227 @default.
- W3311279 cites W175060409 @default.
- W3311279 cites W1753600213 @default.
- W3311279 cites W1836264495 @default.
- W3311279 cites W1899931441 @default.
- W3311279 cites W1916325225 @default.
- W3311279 cites W1936556582 @default.
- W3311279 cites W1946395217 @default.
- W3311279 cites W1949150282 @default.
- W3311279 cites W1951912397 @default.
- W3311279 cites W1960403558 @default.
- W3311279 cites W1965016588 @default.
- W3311279 cites W1969940055 @default.
- W3311279 cites W1973611733 @default.
- W3311279 cites W1974721772 @default.
- W3311279 cites W1974861506 @default.
- W3311279 cites W1975644140 @default.
- W3311279 cites W1976015057 @default.
- W3311279 cites W1977419529 @default.
- W3311279 cites W1977759172 @default.
- W3311279 cites W1978769265 @default.
- W3311279 cites W1981416797 @default.
- W3311279 cites W1981946128 @default.
- W3311279 cites W1984895636 @default.
- W3311279 cites W1985574025 @default.
- W3311279 cites W1990705362 @default.
- W3311279 cites W1991873334 @default.
- W3311279 cites W1994058871 @default.
- W3311279 cites W1994285647 @default.
- W3311279 cites W1994906647 @default.
- W3311279 cites W1995486091 @default.
- W3311279 cites W1997963683 @default.
- W3311279 cites W1999370956 @default.
- W3311279 cites W2001682487 @default.
- W3311279 cites W2004563773 @default.
- W3311279 cites W2007010364 @default.
- W3311279 cites W2007105213 @default.
- W3311279 cites W2007576775 @default.
- W3311279 cites W2008802667 @default.
- W3311279 cites W2015162225 @default.
- W3311279 cites W2021928411 @default.
- W3311279 cites W2022576391 @default.
- W3311279 cites W2028574732 @default.
- W3311279 cites W2029180509 @default.
- W3311279 cites W2030640712 @default.
- W3311279 cites W2034252391 @default.
- W3311279 cites W2037618359 @default.
- W3311279 cites W2039907346 @default.
- W3311279 cites W2042529907 @default.
- W3311279 cites W2043304289 @default.
- W3311279 cites W2044984503 @default.
- W3311279 cites W2046200770 @default.
- W3311279 cites W2048009644 @default.
- W3311279 cites W2052893592 @default.
- W3311279 cites W2056299665 @default.
- W3311279 cites W2064353785 @default.
- W3311279 cites W2067782978 @default.
- W3311279 cites W2071013572 @default.
- W3311279 cites W2075240053 @default.
- W3311279 cites W2077547820 @default.
- W3311279 cites W2077863888 @default.
- W3311279 cites W207968874 @default.
- W3311279 cites W2080627493 @default.
- W3311279 cites W2081162550 @default.
- W3311279 cites W2085422902 @default.
- W3311279 cites W2087323996 @default.
- W3311279 cites W2090906017 @default.
- W3311279 cites W2092855589 @default.
- W3311279 cites W2094427796 @default.
- W3311279 cites W2094434685 @default.
- W3311279 cites W2095523666 @default.
- W3311279 cites W2096785162 @default.
- W3311279 cites W2101690969 @default.
- W3311279 cites W2112066577 @default.
- W3311279 cites W2115000954 @default.
- W3311279 cites W2115619772 @default.
- W3311279 cites W2117118271 @default.
- W3311279 cites W2117895484 @default.
- W3311279 cites W2119755757 @default.
- W3311279 cites W2131700426 @default.
- W3311279 cites W2145557962 @default.
- W3311279 cites W2145619250 @default.
- W3311279 cites W2149272061 @default.
- W3311279 cites W2151429702 @default.
- W3311279 cites W2167643094 @default.
- W3311279 cites W2200967932 @default.
- W3311279 cites W2303261936 @default.
- W3311279 cites W2325288879 @default.
- W3311279 cites W2328784478 @default.
- W3311279 cites W2330945089 @default.