Matches in SemOpenAlex for { <https://semopenalex.org/work/W331284098> ?p ?o ?g. }
- W331284098 abstract "Avian leukosis virus subgroup J (ALV-J) can cause several different leukemia-like proliferative diseases in the hemopoietic system of chickens. Here, we investigated the transcriptome profiles and miRNA expression profiles of ALV-J-infected and uninfected chicken spleens to identify the genes and miRNAs related to ALV-J invasion. In total, 252 genes and 167 miRNAs were differentially expressed in ALV-J-infected spleens compared to control uninfected spleens. miR-23b expression was up-regulated in ALV-J-infected spleens compared with the control spleens, and transcriptome analysis revealed that the expression of interferon regulatory factor 1 (IRF1) was down-regulated in ALV-J-infected spleens compared to uninfected spleens. A dual-luciferase reporter assay showed that IRF1 was a direct target of miR-23b. miR-23b overexpression significantly (P = 0.0022) decreased IRF1 mRNA levels and repressed IRF1-3'-UTR reporter activity. In vitro experiments revealed that miR-23b overexpression strengthened ALV-J replication, whereas miR-23b loss of function inhibited ALV-J replication. IRF1 overexpression inhibited ALV-J replication, and IRF1 knockdown enhanced ALV-J replication. Moreover, IRF1 overexpression significantly (P = 0.0014) increased IFN-β expression. In conclusion, these results suggested that miR-23b may play an important role in ALV-J replication by targeting IRF1." @default.
- W331284098 created "2016-06-24" @default.
- W331284098 creator A5002890940 @default.
- W331284098 creator A5003105897 @default.
- W331284098 creator A5016516907 @default.
- W331284098 creator A5016953985 @default.
- W331284098 creator A5024052936 @default.
- W331284098 creator A5026543951 @default.
- W331284098 creator A5033736862 @default.
- W331284098 creator A5064531609 @default.
- W331284098 date "2015-05-18" @default.
- W331284098 modified "2023-10-12" @default.
- W331284098 title "MicroRNA-23b Promotes Avian Leukosis Virus Subgroup J (ALV-J) Replication by Targeting IRF1" @default.
- W331284098 cites W1968969429 @default.
- W331284098 cites W1974654449 @default.
- W331284098 cites W1975744885 @default.
- W331284098 cites W1976246137 @default.
- W331284098 cites W1985055097 @default.
- W331284098 cites W1985831802 @default.
- W331284098 cites W1986769155 @default.
- W331284098 cites W1993902725 @default.
- W331284098 cites W2000058440 @default.
- W331284098 cites W2000329335 @default.
- W331284098 cites W2004714113 @default.
- W331284098 cites W2005496710 @default.
- W331284098 cites W2007463943 @default.
- W331284098 cites W2008802992 @default.
- W331284098 cites W2010461414 @default.
- W331284098 cites W2015954841 @default.
- W331284098 cites W2022230607 @default.
- W331284098 cites W2031431146 @default.
- W331284098 cites W2033595939 @default.
- W331284098 cites W2037060357 @default.
- W331284098 cites W2040766015 @default.
- W331284098 cites W2042845484 @default.
- W331284098 cites W2048511673 @default.
- W331284098 cites W2050152766 @default.
- W331284098 cites W2055129141 @default.
- W331284098 cites W2059073003 @default.
- W331284098 cites W2061510363 @default.
- W331284098 cites W2062730112 @default.
- W331284098 cites W2067141568 @default.
- W331284098 cites W2091774543 @default.
- W331284098 cites W2099457187 @default.
- W331284098 cites W2099738370 @default.
- W331284098 cites W2104872732 @default.
- W331284098 cites W2113174452 @default.
- W331284098 cites W2113390076 @default.
- W331284098 cites W2116302062 @default.
- W331284098 cites W2125929767 @default.
- W331284098 cites W2133464417 @default.
- W331284098 cites W2143145944 @default.
- W331284098 cites W2149385948 @default.
- W331284098 cites W2155089334 @default.
- W331284098 cites W2160894282 @default.
- W331284098 cites W2161161020 @default.
- W331284098 cites W2162457082 @default.
- W331284098 cites W2163853656 @default.
- W331284098 cites W2166240615 @default.
- W331284098 cites W2171296186 @default.
- W331284098 cites W2321443562 @default.
- W331284098 doi "https://doi.org/10.1038/srep10294" @default.
- W331284098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4434839" @default.
- W331284098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25980475" @default.
- W331284098 hasPublicationYear "2015" @default.
- W331284098 type Work @default.
- W331284098 sameAs 331284098 @default.
- W331284098 citedByCount "54" @default.
- W331284098 countsByYear W3312840982016 @default.
- W331284098 countsByYear W3312840982017 @default.
- W331284098 countsByYear W3312840982018 @default.
- W331284098 countsByYear W3312840982019 @default.
- W331284098 countsByYear W3312840982020 @default.
- W331284098 countsByYear W3312840982021 @default.
- W331284098 countsByYear W3312840982022 @default.
- W331284098 countsByYear W3312840982023 @default.
- W331284098 crossrefType "journal-article" @default.
- W331284098 hasAuthorship W331284098A5002890940 @default.
- W331284098 hasAuthorship W331284098A5003105897 @default.
- W331284098 hasAuthorship W331284098A5016516907 @default.
- W331284098 hasAuthorship W331284098A5016953985 @default.
- W331284098 hasAuthorship W331284098A5024052936 @default.
- W331284098 hasAuthorship W331284098A5026543951 @default.
- W331284098 hasAuthorship W331284098A5033736862 @default.
- W331284098 hasAuthorship W331284098A5064531609 @default.
- W331284098 hasBestOaLocation W3312840981 @default.
- W331284098 hasConcept C104317684 @default.
- W331284098 hasConcept C140704245 @default.
- W331284098 hasConcept C145059251 @default.
- W331284098 hasConcept C150194340 @default.
- W331284098 hasConcept C153911025 @default.
- W331284098 hasConcept C159047783 @default.
- W331284098 hasConcept C162317418 @default.
- W331284098 hasConcept C173396325 @default.
- W331284098 hasConcept C2522874641 @default.
- W331284098 hasConcept C32300475 @default.
- W331284098 hasConcept C502942594 @default.
- W331284098 hasConcept C54355233 @default.
- W331284098 hasConcept C86803240 @default.
- W331284098 hasConcept C95444343 @default.