Matches in SemOpenAlex for { <https://semopenalex.org/work/W33130148> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W33130148 abstract "The aim of this study was to establish levels of the enzymes involved in tetrahydrobiopterin (BH4) metabolism in human and rat brain preparations; to determine whether BH4 metabolism is altered in dementia, particularly in relation to senile dementia of the Alzheimer type (SDAT); and to examine the effect of aluminium on BH4 metabolism. Overall BH4 synthesis and dihydropteridine reductase (DHPR) activity were greater in the locus coeruleus than in the neocortex of elderly subjects. Sepiapterin reductase and DHPR activity showed a linear correlation with age in the temporal cortex. DHPR activity in the frontal cortex was relatively constant until the mid 60s and then fell with age. Overall BH4 synthesis showed a non-significant decline in temporal cortex and was significantly reduced in locus coeruleus preparations from SDAT subjects compared to control subjects. As DHPR, sepiapterin reductase and GTP cyclohydrolase activity were unaltered in SDAT we suggested that there is a lesion on the biosynthetic pathway between dihydroneopterin in triphosphate and BH4 in SDAT, possibly at the level of 6-pyruvoyl tetrahydropterin synthase. DHPR activity and BH4 synthesis capacity were unaltered in temporal cortex preparations from Huntingdon's disease subjects indicating that the defect in BH4 metabolism in SDAT is specific to the disease process and not a secondary consequence of dementia. The implications of altered BH4 metabolism in ageing and dementia are discussed. BH4 metabolism was examined in temporal and frontal cortex preparations from 4 subjects who had received peritoneal dialysis treatment. All patients had elevated serum aluminium levels. The data suggests that aluminium may inhibit DHPR activity in the frontal cortex resulting in diminished BH4 levels in the cells which leads to a compensatory increase in the activity of the biosynthetic pathway. Aluminium reversibly inhibited sepiapterin reductase activity in rat brain preparations but did not alter sepiapterin reductase activity in vivo. Overall BH4 synthesis and OTP cyclohydrolase activity were not affected by aluminium in vitro. The biosynthetic pathway was unaltered in rat brain preparations from animals receiving aluminium orally compared to control animals. DHPR activity was unaltered or increased in rat brain preparations from aluminium treated rats compared to the control group." @default.
- W33130148 created "2016-06-24" @default.
- W33130148 creator A5009244395 @default.
- W33130148 date "1987-01-01" @default.
- W33130148 modified "2023-09-23" @default.
- W33130148 title "Tetrahydrobiopterin metabolism in dementia" @default.
- W33130148 hasPublicationYear "1987" @default.
- W33130148 type Work @default.
- W33130148 sameAs 33130148 @default.
- W33130148 citedByCount "0" @default.
- W33130148 crossrefType "dissertation" @default.
- W33130148 hasAuthorship W33130148A5009244395 @default.
- W33130148 hasConcept C126322002 @default.
- W33130148 hasConcept C134018914 @default.
- W33130148 hasConcept C181199279 @default.
- W33130148 hasConcept C185592680 @default.
- W33130148 hasConcept C197957613 @default.
- W33130148 hasConcept C2776145790 @default.
- W33130148 hasConcept C2777451243 @default.
- W33130148 hasConcept C2778468602 @default.
- W33130148 hasConcept C2779134260 @default.
- W33130148 hasConcept C2779483572 @default.
- W33130148 hasConcept C502032728 @default.
- W33130148 hasConcept C529278444 @default.
- W33130148 hasConcept C55493867 @default.
- W33130148 hasConcept C62231903 @default.
- W33130148 hasConcept C71924100 @default.
- W33130148 hasConcept C86803240 @default.
- W33130148 hasConceptScore W33130148C126322002 @default.
- W33130148 hasConceptScore W33130148C134018914 @default.
- W33130148 hasConceptScore W33130148C181199279 @default.
- W33130148 hasConceptScore W33130148C185592680 @default.
- W33130148 hasConceptScore W33130148C197957613 @default.
- W33130148 hasConceptScore W33130148C2776145790 @default.
- W33130148 hasConceptScore W33130148C2777451243 @default.
- W33130148 hasConceptScore W33130148C2778468602 @default.
- W33130148 hasConceptScore W33130148C2779134260 @default.
- W33130148 hasConceptScore W33130148C2779483572 @default.
- W33130148 hasConceptScore W33130148C502032728 @default.
- W33130148 hasConceptScore W33130148C529278444 @default.
- W33130148 hasConceptScore W33130148C55493867 @default.
- W33130148 hasConceptScore W33130148C62231903 @default.
- W33130148 hasConceptScore W33130148C71924100 @default.
- W33130148 hasConceptScore W33130148C86803240 @default.
- W33130148 hasLocation W331301481 @default.
- W33130148 hasOpenAccess W33130148 @default.
- W33130148 hasPrimaryLocation W331301481 @default.
- W33130148 hasRelatedWork W1984628764 @default.
- W33130148 hasRelatedWork W2021120295 @default.
- W33130148 hasRelatedWork W2021176894 @default.
- W33130148 hasRelatedWork W2035873511 @default.
- W33130148 hasRelatedWork W2035914400 @default.
- W33130148 hasRelatedWork W2040467992 @default.
- W33130148 hasRelatedWork W2042984230 @default.
- W33130148 hasRelatedWork W2054991567 @default.
- W33130148 hasRelatedWork W2067621144 @default.
- W33130148 hasRelatedWork W2069491991 @default.
- W33130148 hasRelatedWork W2076410603 @default.
- W33130148 hasRelatedWork W2151997912 @default.
- W33130148 hasRelatedWork W2411368254 @default.
- W33130148 hasRelatedWork W2413765590 @default.
- W33130148 hasRelatedWork W27428450 @default.
- W33130148 hasRelatedWork W2769463448 @default.
- W33130148 hasRelatedWork W2884497078 @default.
- W33130148 hasRelatedWork W2922034480 @default.
- W33130148 hasRelatedWork W3093777245 @default.
- W33130148 hasRelatedWork W3211574812 @default.
- W33130148 isParatext "false" @default.
- W33130148 isRetracted "false" @default.
- W33130148 magId "33130148" @default.
- W33130148 workType "dissertation" @default.