FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W331378171> ?p ?o ?g. }

• W331378171 endingPage "11" @default.
• W331378171 startingPage "1" @default.
• W331378171 abstract "Background: Differentiation of mesenchymal stem cells (MSCs) to hepatocyte-li ke cells could be associated with development of liver function factors. The impact of differentiation-dependent changes on DNA integrity is not well understood. In this study, hepatocytes and their progenitor stem cells were treated with aflatoxin B1 (AFB1) and amplification of selected genes linked to DNA damage was examined. Methods: MSCs and CD34 + cells isolated from umbilical cord blood (UCB) were treated with AFB1 (0, 2.5, 10 and 20 µM) in selective media supporting the hepatocyte differentiation. After 24 htreatment the DNA damage (Comet assay) and amplification rates of P53 and �� -globin genes were measured using real time polymerase chain reaction (QPCR). Results: The results show that AFB1 treatments resulted in a concentration- dependent increase in the DNA damage and suppression of the specific gene amplification. The extent of DNA damage was significantly greater in hepatocytes differentiated from MSCs when compared to those obtained from CD34 + cells. The effects of AFB1 on the rate of selected gene amplification in QPCR showed that the lesions (expressed as lesions/10 kb) in P53 and �� -globin genes was significantly greater in hepatocytes derived from MSCs as compared to the cells derived from CD34 + cells. Conclusions: These data together with the results of cytochrome P450 (CYP3A4) expression in the cells suggest that the non-differentiated stem cells are probably less vulnerable to genotoxic agents as compared to hepatocytes differentiated from them." @default.
• W331378171 created "2016-06-24" @default.
• W331378171 creator A5024971399 @default.
• W331378171 creator A5028843604 @default.
• W331378171 creator A5052357123 @default.
• W331378171 creator A5068495881 @default.
• W331378171 creator A5085895836 @default.
• W331378171 date "2014-01-01" @default.
• W331378171 modified "2023-09-26" @default.
• W331378171 title "Effects of aflatoxin B1 on DNA damage and P53geneamplification in hepatocyte-like cells differentiated from mesenchymal stem cells and CD34+ cellsobtained fromhuman umbilical cord blood" @default.
• W331378171 cites W1612859952 @default.
• W331378171 cites W1975537799 @default.
• W331378171 cites W1996884864 @default.
• W331378171 cites W2009040628 @default.
• W331378171 cites W2015961312 @default.
• W331378171 cites W2017696550 @default.
• W331378171 cites W2022183936 @default.
• W331378171 cites W2030299494 @default.
• W331378171 cites W2037703366 @default.
• W331378171 cites W2054939637 @default.
• W331378171 cites W2055335794 @default.
• W331378171 cites W2066413879 @default.
• W331378171 cites W2073723117 @default.
• W331378171 cites W2082935970 @default.
• W331378171 cites W2084652820 @default.
• W331378171 cites W2088662061 @default.
• W331378171 cites W2090158530 @default.
• W331378171 cites W2091156312 @default.
• W331378171 cites W2094290627 @default.
• W331378171 cites W2097879198 @default.
• W331378171 cites W2100585305 @default.
• W331378171 cites W2111876442 @default.
• W331378171 cites W2114692975 @default.
• W331378171 cites W2157830903 @default.
• W331378171 cites W2159999899 @default.
• W331378171 cites W55405400 @default.
• W331378171 hasPublicationYear "2014" @default.
• W331378171 type Work @default.
• W331378171 sameAs 331378171 @default.
• W331378171 citedByCount "0" @default.
• W331378171 crossrefType "journal-article" @default.
• W331378171 hasAuthorship W331378171A5024971399 @default.
• W331378171 hasAuthorship W331378171A5028843604 @default.
• W331378171 hasAuthorship W331378171A5052357123 @default.
• W331378171 hasAuthorship W331378171A5068495881 @default.
• W331378171 hasAuthorship W331378171A5085895836 @default.
• W331378171 hasConcept C10205521 @default.
• W331378171 hasConcept C104317684 @default.
• W331378171 hasConcept C148738053 @default.
• W331378171 hasConcept C153911025 @default.
• W331378171 hasConcept C198826908 @default.
• W331378171 hasConcept C201750760 @default.
• W331378171 hasConcept C202751555 @default.
• W331378171 hasConcept C203014093 @default.
• W331378171 hasConcept C2776200302 @default.
• W331378171 hasConcept C2776955114 @default.
• W331378171 hasConcept C28328180 @default.
• W331378171 hasConcept C54355233 @default.
• W331378171 hasConcept C86803240 @default.
• W331378171 hasConcept C95444343 @default.
• W331378171 hasConceptScore W331378171C10205521 @default.
• W331378171 hasConceptScore W331378171C104317684 @default.
• W331378171 hasConceptScore W331378171C148738053 @default.
• W331378171 hasConceptScore W331378171C153911025 @default.
• W331378171 hasConceptScore W331378171C198826908 @default.
• W331378171 hasConceptScore W331378171C201750760 @default.
• W331378171 hasConceptScore W331378171C202751555 @default.
• W331378171 hasConceptScore W331378171C203014093 @default.
• W331378171 hasConceptScore W331378171C2776200302 @default.
• W331378171 hasConceptScore W331378171C2776955114 @default.
• W331378171 hasConceptScore W331378171C28328180 @default.
• W331378171 hasConceptScore W331378171C54355233 @default.
• W331378171 hasConceptScore W331378171C86803240 @default.
• W331378171 hasConceptScore W331378171C95444343 @default.
• W331378171 hasIssue "1" @default.
• W331378171 hasOpenAccess W331378171 @default.
• W331378171 hasRelatedWork W1549322212 @default.
• W331378171 hasRelatedWork W2023875843 @default.
• W331378171 hasRelatedWork W2057617985 @default.
• W331378171 hasRelatedWork W2059108509 @default.
• W331378171 hasRelatedWork W2090158530 @default.
• W331378171 hasRelatedWork W2099019662 @default.
• W331378171 hasRelatedWork W2133970298 @default.
• W331378171 hasRelatedWork W2359293853 @default.
• W331378171 hasRelatedWork W2361235744 @default.
• W331378171 hasRelatedWork W2370350167 @default.
• W331378171 hasRelatedWork W2384293616 @default.
• W331378171 hasRelatedWork W2384531619 @default.
• W331378171 hasRelatedWork W2388037631 @default.
• W331378171 hasRelatedWork W2400305972 @default.
• W331378171 hasRelatedWork W2440869274 @default.
• W331378171 hasRelatedWork W2758579584 @default.
• W331378171 hasRelatedWork W2967013407 @default.
• W331378171 hasRelatedWork W3028873668 @default.
• W331378171 hasRelatedWork W3031843476 @default.
• W331378171 hasRelatedWork W624146369 @default.
• W331378171 hasVolume "1" @default.
• W331378171 isParatext "false" @default.

• next